Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Circadian Rhythm: An Influential Soundtrack in the Diabetes Story Publisher

Summary: Research shows disrupted body clocks may worsen type 2 diabetes, suggesting timed therapies could help. #DiabetesCare #CircadianRhythm

Hariri A1 ; Mirian M1 ; Zarrabi A2 ; Kohandel M3 ; Aminipozveh M4 ; Aref AR5, 6 ; Tabatabaee A7 ; Prabhakar PK8, 9 ; Sivakumar PM10, 11
Authors

Source: Frontiers in Endocrinology Published:2023


Abstract

Type 2 Diabetes Mellitus (T2DM) has been the main category of metabolic diseases in recent years due to changes in lifestyle and environmental conditions such as diet and physical activity. On the other hand, the circadian rhythm is one of the most significant biological pathways in humans and other mammals, which is affected by light, sleep, and human activity. However, this cycle is controlled via complicated cellular pathways with feedback loops. It is widely known that changes in the circadian rhythm can alter some metabolic pathways of body cells and could affect the treatment process, particularly for metabolic diseases like T2DM. The aim of this study is to explore the importance of the circadian rhythm in the occurrence of T2DM via reviewing the metabolic pathways involved, their relationship with the circadian rhythm from two perspectives, lifestyle and molecular pathways, and their effect on T2DM pathophysiology. These impacts have been demonstrated in a variety of studies and led to the development of approaches such as time-restricted feeding, chronotherapy (time-specific therapies), and circadian molecule stabilizers. Copyright © 2023 Hariri, Mirian, Zarrabi, Kohandel, Amini-Pozveh, Aref, Tabatabaee, Prabhakar and Sivakumar.
Other Related Docs