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The Circadian Rhythm: An Influential Soundtrack in the Diabetes Story Publisher



Hariri A1 ; Mirian M1 ; Zarrabi A2 ; Kohandel M3 ; Aminipozveh M4 ; Aref AR5, 6 ; Tabatabaee A7 ; Prabhakar PK8, 9 ; Sivakumar PM10, 11
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Turkiye
  3. 3. Department of Applied Mathematics, Faculty of Mathematics, University of Waterloo, Waterloo, ON, Canada
  4. 4. Department of Prosthodontics Dentistry, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Belfer Center for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA, United States
  6. 6. Translational Sciences, Xsphera Biosciences Inc, Boston, MA, United States
  7. 7. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Lovely Professional University, Punjab, Phagwara, India
  9. 9. Division of Research and Development, Lovely Professional University, Punjab, Phagwara, India
  10. 10. Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam
  11. 11. School of Medicine and Pharmacy, Duy Tan University, Da Nang, Viet Nam

Source: Frontiers in Endocrinology Published:2023


Abstract

Type 2 Diabetes Mellitus (T2DM) has been the main category of metabolic diseases in recent years due to changes in lifestyle and environmental conditions such as diet and physical activity. On the other hand, the circadian rhythm is one of the most significant biological pathways in humans and other mammals, which is affected by light, sleep, and human activity. However, this cycle is controlled via complicated cellular pathways with feedback loops. It is widely known that changes in the circadian rhythm can alter some metabolic pathways of body cells and could affect the treatment process, particularly for metabolic diseases like T2DM. The aim of this study is to explore the importance of the circadian rhythm in the occurrence of T2DM via reviewing the metabolic pathways involved, their relationship with the circadian rhythm from two perspectives, lifestyle and molecular pathways, and their effect on T2DM pathophysiology. These impacts have been demonstrated in a variety of studies and led to the development of approaches such as time-restricted feeding, chronotherapy (time-specific therapies), and circadian molecule stabilizers. Copyright © 2023 Hariri, Mirian, Zarrabi, Kohandel, Amini-Pozveh, Aref, Tabatabaee, Prabhakar and Sivakumar.
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