Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Simvastatin on Kinetics of Osteoprotegrin/Receptor Activator Nuclear Kappa B Ligand Mrna Expression in Periapical Lesions Publisher Pubmed



Shadmehr E1 ; Khademi A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Endodontics and Torabinejad Research Center, Esfahan Dental College, Esfahan, Iran

Source: International Endodontic Journal Published:2013


Abstract

Aim: To evaluate the therapeutic effect of Simvastatin on apical periodontitis in rats by assessing the osteoblast production of receptor activator of nuclear factor-Kappa B Ligand (RANKL) and Osteoprotegerin (OPG) cytokines that are essential for bone resorption. Methodology: Twenty-five healthy 8- to 10-week-old male rats were selected. Periapical lesions were induced by exposure of pulps through the occlusal surfaces of mandibular first molars. The pulps were extirpated and canals contaminated with saliva. The teeth were filled temporarily to make animal feeding feasible. The experimental group (n = 12) was placed on 20 mg-1 kg-1 day-1 of Simvastatin for 10 days (3 days before and 7 days after pulp exposure) and the control group (n = 12) received a placebo. After 1, 2 and 4 weeks, the animals were sacrificed and mRNA expression of OPG/RANKL was evaluated by real-time PCR. One rat was sacrificed without any interventions (negative control) to determine the baseline expression of the mediators involved. Data were analysed by one-way anova. Results: Simvastatin significantly (P < 0.05) enhanced the expression of OPG and reduced the mRNA expression of RANKL in the experimental group compared with the control group. Conclusions: Oral administration of Simvastatin attenuated RANKL expression and accelerated OPG expression in induced rat periapical lesions. © 2013 International Endodontic Journal.
Related Docs
View other Related Docs
1. The Effects of Simvastatin on Bone Remodeling, Tooth Movement and Root Resorption in Orthodontic Treatments, Biomedical and Pharmacology Journal (2013)
2. The Effects of Statins on Dental and Oral Health: A Review of Preclinical and Clinical Studies, Journal of Translational Medicine (2020)
3. The Effects of Local Injection of Simvastatin on Tooth Movement and Root Resorption Rates Under Orthodontic Forces in Dogs, Biosciences Biotechnology Research Asia (2014)
4. Effectiveness of Local Application of Simvastatin for Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: An Animal Study on Rats, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (2022)
5. Histopathological Assessment of the Preventive Effect of Leukocyte-Platelet-Rich Fibrin on Bisphosphonate-Related Osteonecrosis of the Jaw Following Dental Extraction: An Animal Study, Heliyon (2023)
6. Evaluation of the Effects of Two Different Bone Resorption Inhibitors on Osteoclast Numbers and Activity: An Animal Study, Dental Research Journal (2016)
7. Sealing Ability of Mta and Cem Cement As Root-End Fillings of Human Teeth in Dry, Saliva or Bloodcontaminated Conditions, Iranian Endodontic Journal (2010)
8. Histological Evaluation of Proroot Mineral Trioxide Aggregate and Cold Ceramic As Root-End Filling Materials in Animal Models, Dental Research Journal (2023)
Experts (# of related papers)
View all Related Experts
Sayed Mohammad Razavi (16)
Abbasali Khademi (6)
Other Related Docs
9. Atorvastatin Effect on Systemic Lupus Erythematosus Disease Activity: A Double-Blind Randomized Clinical Trial, Clinical Rheumatology (2014)
10. In Vitro Evaluation of Dentin Tubule Occlusion by Three Bioactive Materials: A Scanning Electron Microscopic Study, Dental Research Journal (2019)
11. Comparative Effectiveness of Hand and Ultrasonic Instrumentations in Root Surface Planing in Vitro, Journal of Clinical Periodontology (2004)
12. Temporal Expression Pattern of Sodium Channel Nav 1.8 Messenger Rna in Pulpitis, International Endodontic Journal (2011)
13. The Effect of Micro‑Osteoperforation on Root Resorption,Pulp Vitality, and Biological Changes of Teeth Subjected to Orthodontic Tooth Movement:A Systematic Review Study, Dental Research Journal (2023)
14. Human Pulp Response to Direct Pulp Capping and Miniature Pulpotomy With Mta After Application of Topical Dexamethasone: A Randomized Clinical Trial, Iranian Endodontic Journal (2016)
15. Effect of Different Protective Bases on Ph Changes and Hydrogen Peroxide Microleakage During Intracoronal Bleaching, Frontiers in Dentistry (2023)
16. The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women, Journal of Isfahan Medical School (2014)
17. Hard Tissue Formation in Pulpotomized Primary Teeth in Dogs With Nanomaterials Mcm-48 and Mcm-48/Hydroxyapatite: An in Vivo Animal Study, BMC Oral Health (2024)
18. The Accuracy of Three Apex Locators in Determining the Location of Strip Root Perforation in Different Environments, Iranian Endodontic Journal (2021)
19. Effects of Chitosan As a Novel Obturation Material for Pulpectomized Teeth on Periapical Inflammation, Periodontal Ligament Widening, and Hard Tissue Resorption: A Preliminary Exploratory Study on Dogs, Frontiers in Dentistry (2024)
20. Protective Effects of Resveratrol Against Osteonecrosis at the Extraction Site in Bisphosphonate-Treated Rats, International Journal of Oral and Maxillofacial Surgery (2020)
21. Comparison of Periapical Parallel Radiography With Cbct With Different Field of Views (Fov) for the Detection of Periapical Lesions, Dental Research Journal (2024)
22. The Effect of Melatonin on Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: An Animal Study in Rats, Journal of the Korean Association of Oral and Maxillofacial Surgeons (2020)
23. Effect of Duration of Root Canal Infection on the Ability of Dentin-Pulp Complex Regeneration of Immature Permanent Teeth: An Animal Study, Journal of Endodontics (2022)
24. Histologic Evaluation of Apical Pulp of Immature Apex Following Extraction, Surface Treatment, and Replantation in Different Storage Media in Dogs, Dental Traumatology (2015)
25. The Effect of Vitamin E Supplementation on Treatment of Chronic Periodontitis, Dental Research Journal (2021)
26. Improving Pulp Revascularization Outcomes With Buccal Fat Autotransplantation, Journal of Tissue Engineering and Regenerative Medicine (2020)
27. Systemic Effects of Fluoxetine on the Amount of Tooth Movement, Root Resorption, and Alveolar Bone Remodeling During Orthodontic Force Application in Rat, Dental Research Journal (2015)
28. Effect of Buccal Fat Autotransplantation on Improving the Alveolar Socket Bone Regeneration: An In-Vivo Study, Heliyon (2024)
29. Cytotoxicity of Two Different Intercanal Medicaments on Human Gingival Fibroblasts-A Laboratory Study, Endodontology (2022)
30. Efficacy of the Systemic Co-Administration of Vitamin D3 in Reversing the Inhibitory Effects of Sodium Alendronate on Orthodontic Tooth Movement: A Preliminary Experimental Animal Study, American Journal of Orthodontics and Dentofacial Orthopedics (2022)
31. Local Single-Dose Teriparatide Administration for Bronj Prevention: Insights From a Rat Model Study, Journal of Maxillofacial and Oral Surgery (2024)
32. Pulp Response Following Direct Pulp Capping With Dentin Adhesives and Mineral Trioxide Aggregate; an Animal Study, Iranian Endodontic Journal (2017)
33. Mineral Trioxide Aggregate (Mta) and Calcium Hydroxide As Pulp-Capping Agents in Human Teeth: A Preliminary Report, International Endodontic Journal (2003)
34. Systemic Supplement With Resveratrol Increased Bone Formation in Rats’ Alveolar Socket; [Aumento De La Formacion Osea En El Hueso Alveolar De Rata Con Suplemento Sistemico Con Resveratrol], International Journal of Morphology (2018)
35. Evaluation of Salivary Calcium, Phosphorus and Alkaline Phosphatase Concentrations Before and After the First Phase of Periodontal Treatment in Patients With Chronic Periodontitis, Journal of Advanced Periodontology and Implant Dentistry (2020)
36. Use of Aminoguanidine, a Selective Inducible Nitric Oxide Synthase Inhibitor, to Evaluate the Role of Nitric Oxide in Periapical Inflammation., Journal of oral science (2011)
37. Periodontal Healing of Replanted Dog Teeth Stored in Milk and Egg Albumen, Dental Traumatology (2008)
38. Dental Implants: Early Versus Standard Two-Stage Loading (Animal Study), Journal of Oral Implantology (2014)
39. Histological Characteristics of Dental Pulp in Teeth With Periodontal Problems and Healthy Teeth, Journal of Advanced Periodontology and Implant Dentistry (2023)
40. Effect of Citric Acid Versus Edta on Radiographic Root Development in Regenerative Endodontic Treatment: An Animal Study, Journal of Endodontics (2022)
41. Histologic Evaluation of Human Pulp Response to Total Etch and Self Etch Adhesive Systems, Iranian Red Crescent Medical Journal (2013)
42. Histopathologic Evaluation of Subcutaneous Tissue Response to Three Endodontic Sealers in Rats., Journal of oral science (2011)
43. Visfatin Expression in Gingival Tissues of Chronic Periodontitis and Aggressive Periodontitis Patients: An Immunohistochemical Analysis, Dental Research Journal (2018)
44. Comparison of the Accuracy of Apex Locator, Digital Radiography, and Cone-Beam Computed Tomography in Root Canal Working Length Determination in Teeth With External Root Resorption: An in Vitro Study, Dental Research Journal (2024)
45. Hyalinization and Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis, Pesquisa Brasileira em Odontopediatria e Clinica Integrada (2020)