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The Effects of Simvastatin on Bone Remodeling, Tooth Movement and Root Resorption in Orthodontic Treatments Publisher



Esfahani NE1 ; Sadeghian S2 ; Razavi SM3 ; Minaiyan M4 ; Afsari E5
Authors
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Authors Affiliations
  1. 1. Department of Orthodontics, Khorasgan (Isfahan) Branch, Islamic Azad University, Isfahan, Iran
  2. 2. Departement of Orthodontics, Khorasgan (Isfahan) Branch, Islamic Azad University, Isfahan, Iran
  3. 3. Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Science, Iran
  4. 4. Department of Pharmacology, School of Pharmacy, Isfahan University of Medical Science, Isfahan, Iran
  5. 5. Azad University of Khorasgan, Isfahan, Iran

Source: Biomedical and Pharmacology Journal Published:2013


Abstract

Simvastatin is widely used for lowering serum cholesterol, and also has protective effect on bone metabolism. The aim of this study was to evaluate Simvastatin effect on alveolar bone remodeling, root resorption and amount of tooth movement during orthodontic treatment in rats. In this animal study, 32 adult male rats were randomly divided in two groups. After application of a nickel titanium closed-coil spring with 60 g force between the maxillary central incisor and maxillary first molar, animals in the experimented group began receiving Simvastatin at a dose of 2.5 mg per kilogram per day for 17 days, and animals in the control group received normal saline. The distance between teeth was measured on 1 and 17 days. Two animals from each group were killed at 4, 7, and 17 days. Histo morphometric analyses of bone mineral appositional rate, percentage of root resorption area, and number of resorption lacunae of maxillary first molar mesiobuccal root were done. T-test independent were done for statistical analysis.The rats in experimental group showed significantly decrease of tooth movement (p<0.024). Mineral apposition rate at 7 and 17 days were increased significantly in experimental group(p<0.05). Percentage of root resorption and number of root resorption lacunae at 4,7 and 17 days were decreased significantly in experimental group(p<0.05). The result of this study showed Although Simvastatin might decrease root resorption related to orthodontic tooth movement, patients and clinicians should be informed about a possible decrease in the amount of tooth movement and a prolonged period of orthodontic treatment.
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