Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Vascular Endothelial Function in Health and Diseases Publisher



Khazaei M1 ; Moienafshari F2 ; Laher I2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada

Source: Pathophysiology Published:2008


Abstract

The vascular endothelium constitutes approximately 1% of body mass (1 kg) and has a surface area of approximately 5000 m2. The endothelium is a multifunctional endocrine organ strategically placed between the vessel wall and the circulating blood, and has a key role in vascular homeostasis. The endothelium is both a target for and mediator of cardiovascular disease. The endothelium releases several relaxing and constricting factors, which can affect vascular homeostasis. Endothelial dysfunction, whether caused by physical injury or cellular damage, leads to compensatory responses that alter the normal homeostatic properties of the endothelium. In this review, we summarized some physiological aspects of endothelial function and then we discussed endothelial dysfunction during some pathological conditions. © 2008 Elsevier Ireland Ltd. All rights reserved.
Related Docs
View other Related Docs
1. Exercise Restores Coronary Vascular Function Independent of Myogenic Tone or Hyperglycemic Status in Db/Db Mice, American Journal of Physiology - Heart and Circulatory Physiology (2008)
2. Endothelial Function and Dysfunction: Clinical Significance and Assessment, Journal of Research in Medical Sciences (2008)
3. High Blood Pressure and Endothelial Dysfunction: Effects of High Blood Pressure Medications on Endothelial Dysfunction and New Treatments, Journal of Research in Medical Sciences (2012)
4. Anti-Atherosclerotic Effects of Vitamins D and E in Suppression of Atherogenesis, Journal of Cellular Physiology (2017)
5. Effect of Exercise on Augmented Aortic Vasoconstriction in the Db/Db Mouse Model of Type-Ii Diabetes, Physiological Research (2008)
6. The Effect of Maintenance and Reversal of Doca-Salt Hypertension on Extravasation of Macromolecules and Serum Nitric Oxide Concentration in Male Rats, Pathophysiology (2011)
7. The Effects of Diethyldithiocarbamate, a Sod Inhibitor, on Endothelial Function in Sedentary and Exercised Db/Db Mice, Pathophysiology (2009)
8. The Effect of Hypertension on Serum Nitric Oxide and Vascular Endothelial Growth Factor Concentrations. a Study in Doca-Salt Hypertensive Ovariectomized Rats, Regulatory Peptides (2006)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (6)
Shaghayegh Haghjooy Javanmard (5)
Other Related Docs
9. Sex Difference in Gentamicin-Induced Nephrotoxicity: Influence of L-Arginine in Rat Model, International Journal of Preventive Medicine (2018)
10. Endothelial Function in Male Body Builders Taking Anabolic Androgenic Steroids, Journal of Research in Medical Sciences (2005)
11. Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti-Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects, Phytotherapy Research (2014)
12. Changes of Plasma Angiogenic Factors During Chronic Resistance Exercise in Type I Diabetic Rats, Pakistan Journal of Medical Sciences (2012)
13. Serum Level of Vascular Endothelial Growth Factor Is Increased by Estrogen Replacement Therapy in Normotensive and Doca-Salt Hypertensive Ovariectomized Rats, Clinica Chimica Acta (2006)
14. Effect of Hypertension and Its Reverse on Serum Nitric Oxide Concentration and Vascular Permeability in Two-Kidney One-Clip Hypertensive Rats, General Physiology and Biophysics (2011)
15. Low Dose of L-Arginine Does Not Change Endothelial Permeability of Aorta and Coronary Arteries in Rat, Pakistan Journal of Nutrition (2008)
16. Cytoprotective Effect of Hydroalcoholic Extract of Pinus Eldarica Bark Against H2o2-Induced Oxidative Stress in Human Endothelial Cells, Iranian Biomedical Journal (2016)
17. The Effects of L-Arginine (The Precursor of Nitric Oxide) and L-Name (Nitric Oxide Synthase Inhibitor) on Coronary Angiogenesis in Normal Rats, Journal of Isfahan Medical School (2011)
18. Antiphospholipid Antibodies: Paradigm in Transition, Journal of Neuroinflammation (2009)
19. Oxidative Stress and Hypertension: Possibility of Hypertension Therapy With Antioxidants, Journal of Research in Medical Sciences (2014)
20. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes, International Journal of Preventive Medicine (2014)
21. Histological Assessment of the Local Effect of Different Concentrations of Aminoguanidine Hydrochloride on Bone Healing in Rats, Dental Research Journal (2021)
22. Effect of Chronic L-Arginine Supplementation on Aortic Fatty Streak Formation and Serum Nitric Oxide Concentration in Normal and High-Cholesterol Fed Rabbits, Acta Physiologica Hungarica (2012)
23. Coronary Vascular and Aortic Endothelial Permeability During Estrogen Therapy: A Study in Doca-Salt Hypertensive Ovariectomized Rats, Physiological Research (2004)
24. Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice, Mediators of Inflammation (2010)
25. Effects of Iron and Vitamin E on Endothelial Permeability of Aorta and Coronary Arteries in Rabbits on a High-Cholesterol Diet, Journal of Isfahan Medical School (2011)
26. The Molecular Basis of Covid-19 Pathogenesis, Conventional and Nanomedicine Therapy, International Journal of Molecular Sciences (2021)
27. Effects of Diabetes on Myocardial Capillary Density and Serum Angiogenesis Biomarkers in Male Rats, Clinics (2011)
28. The Effects of Quercetin Supplementation on Endothelial Function, Oxidative Stress, Athletic Performance, Inflammatory Biomarkers and Muscle Damage Indices in Athletes, Journal of Isfahan Medical School (2012)