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View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury Publisher Pubmed



Karimi F1 ; Maleki M2 ; Nematbakhsh M3
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Behbahan Faculty of Medical Sciences, Behbahan, Iran
  2. 2. Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  3. 3. Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System Published:2022


Abstract

Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptor (AT1R)) and nonconventional (ACE2, Ang 1-7, Ang 1-9, AT2 receptor (AT2R), and Mas receptor (MasR)) axes. RIRI alters the balance of both axes so that RAS can affect RIRI-induced AKI. In overall, the alteration of Ang II/AT1R and AKI by RIRI is important to consider. This review has looked for the effects and interactions of RAS activities during RIRI conditions. 2022, SAGE Publications Ltd. All rights reserved.
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