Reducing Cardiac Steatosis: Interventions to Improve Diastolic Function: A Narrative Review Publisher Pubmed



Heshmatghahdarijani K¹ ; Modaresi R² ; Pourmasjedi S¹ ; Sotoudehnia Korani S^{3, 4} ; Rezazadeh Roudkoli A³ ; Ziaei R⁵ ; Farid A⁶ ; Salehi M⁷ ; Heidari A² ; Neshat S² Show Affiliations
Source: Current Problems in Cardiology Published:2023

Abstract

Heart failure is one of the main causes of morbidity and mortality around the globe. Heart failure with preserved ejection fraction is primarily caused by diastolic dysfunction. Adipose tissue deposition in the heart has been previously explained in the pathogenesis of diastolic dysfunction. In this article, we aim to discuss the potential interventions that can reduce the risk of diastolic dysfunction by reducing cardiac adipose tissue. A healthy diet with reduced dietary fat content can reduce visceral adiposity and improve diastolic function. Aerobic and resistance exercises also reduce visceral and epicardial fat and ameliorate diastolic dysfunction. Some medications, include metformin, glucagon-like peptide-1 analogues, dipeptidyl peptidase-4 inhibitors, thiazolidinediones, sodium-glucose co-transporter-2, inhibitors, statins, ACE-Is, and ARBs, have shown different degrees of effectiveness in improving cardiac steatosis and diastolic function. Bariatric surgery has also shown promising results in this field. © 2023 Elsevier Inc.