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Protective Potential of Sodium-Glucose Cotransporter 2 Inhibitors in Internal Medicine (Part 1); [Протективный Потенциал Ингибиторов Натрий-Глюкозного Котранспортера 2 Типа В Клинике Внутренних Болезней (Часть 1)] Publisher



Avagimyan AA11, 12 ; Sheibani M13, 14 ; Trofimenko AI15 ; Lysov EE15 ; Khamidova FM16 ; Aznauryan AZ17 ; Sukiasyan LM18 ; Sahakyan KT17 ; Gevorgyan TR19 ; Tatoyan MR17 ; Mkrtchyan GL17 ; Meltonyan GL17 ; Petrosyan AR20 ; Martemyanova LA21 Show All Authors
Authors
  1. Avagimyan AA11, 12
  2. Sheibani M13, 14
  3. Trofimenko AI15
  4. Lysov EE15
  5. Khamidova FM16
  6. Aznauryan AZ17
  7. Sukiasyan LM18
  8. Sahakyan KT17
  9. Gevorgyan TR19
  10. Tatoyan MR17
  11. Mkrtchyan GL17
  12. Meltonyan GL17
  13. Petrosyan AR20
  14. Martemyanova LA21
  15. Petrosyan RR22
  16. Urazova OI23, 24
  17. Pogosova NV10, 12
  18. Sarrafzadegan N25
Show Affiliations
Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Patrice Lumumba Peoples’ Friendship University of Russia, Moscow, Russian Federation
  3. 3. Iran University of Medical Sciences, Tehran, Iran
  4. 4. Kuban State Medical University, Krasnodar, Russian Federation
  5. 5. Samarkand State Medical University, Samarkand, Uzbekistan
  6. 6. Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  7. 7. Gomel State Medical University, Gomel, Belarus
  8. 8. Lebanese American University, Beirut, Lebanon
  9. 9. Siberian State Medical University, Tomsk, Russian Federation
  10. 10. National Medical Research Centre of Cardiology named after Academician E.I. Chazov, Moscow, Russian Federation
  11. 11. Institute of Cardiovascular Research, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Department of Evidence-Based Medicine, Institute of Medicine, Patrice Lumumba Peoples’ Friendship University of Russia, Moscow, Russian Federation
  13. 13. The Department of Pharmacology
  14. 14. Razi Drug Research Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  15. 15. The Pathological Physiology Department, Kuban State Medical University, Krasnodar, Russian Federation
  16. 16. The Pathological Anatomy Department, Samarkand State Medical University, Samarkand, Uzbekistan
  17. 17. The Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  18. 18. Central Research Laboratory, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  19. 19. The Pediatric Ophthalmology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  20. 20. The Department of Pathological Anatomy and Clinical Morphology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  21. 21. The Pathological Anatomy Department, Gomel State Medical University, Gomel, Belarus
  22. 22. Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon
  23. 23. The Russian Academy of Sciences, Russian Federation
  24. 24. The Patho-physiology Department, Siberian State Medical University, Tomsk, Russian Federation
  25. 25. The Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Innovative Medicine of Kuban Published:2024


Abstract

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a revolutionary class of drugs with far-reaching protective effects in multiple organs. The protective potential of SGLT2i is much broader than that of the classical concept of glucose control and consists of an entire conglomerate of associated pleiotropic effects. This study aims to provide a descriptive review of the pleiotropic therapeutic potential of SGLT2i. The first part of the literature review examined the use of SGLT2i in cardiology and nephrology. The use of SGLT2i represents an innovative approach to improving patients’ quality of life and course of heart failure and chronic kidney disease, regardless of left ventricular ejection fraction and type 2 diabetes. © 2024 Scientific Research Institute — Ochapovsky Clinical Regional Hospital no. 1. All rights reserved.
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