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Brca 1/2 Mutations and Risk of Uterine Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Zakerinasab F1 ; Behfar Q2 ; Parsaee R3 ; Zadeh RH4 ; Foroughi E5 ; Amirbeik A6 ; Ahmadi G1
Authors
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Authors Affiliations
  1. 1. Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
  3. 3. Master Student in Molecular Genetics, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Student’s Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: BMC Genomic Data Published:2024


Abstract

Purpose: In this study, we aim to investigate the association between BRCA1/2 mutation and uterine cancer incidence. Material and method: We systematically searched three databases including PubMed, Scopus, and Google Scholar up to August 2023; and reviewed 23 cohorts and cross-sectional studies to explore the association between BRCA1/2 mutations and uterine cancer incidence. Results: This systematic review comprised a total of 21 cohort studies and 2 cross-sectional studies after the screening process. According to meta-analysis the prevalence of the BRCA1/2 gene in patients with uterine cancer was 0.02 (95%CI = [0.01,0.03], P < 0.01, I2 = 94.82%) Conclusions: Our meta-analysis investigates a 2% prevalence of BRCA1/2 mutation in patients with uterine cancer. Patients with BRCA1/2 mutations might be more conscious of uterine malignancies. © 2024, The Author(s).
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