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Stromal Demarcation Line in Pulsed Versus Continuous Light Accelerated Corneal Crosslinking for Keratoconus Publisher Pubmed



Peyman A1 ; Nouralishahi A1 ; Hafezi F2, 3, 4 ; Kling S4 ; Peyman M5
Authors
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Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, Feiz Hospital, Modares St., Isfahan, Iran
  2. 2. ELZA Institute, Zurich, Switzerland
  3. 3. Department of Ophthalmology, University of Southern California-Los Angeles, Los Angeles, CA, United States
  4. 4. Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland
  5. 5. Department of Ophthalmology, University of Malaya, Kuala Lumpur, Malaysia

Source: Journal of Refractive Surgery Published:2016


Abstract

PURPOSE: To compare the stromal demarcation line depth in pulsed versus continuous corneal cross-linking (CXL) for keratoconus. METHODS: Seventy eyes underwent epithelium-off cross-linking, with 0.1% riboflavin applied during 10 minutes prior to ultraviolet irradiation at 30 mW/cm2. Thirty-six eyes received pulsed irradiation (1 second on, 1 second off) for 8 minutes and 34 eyes underwent continuous irradiation for 4 minutes. Total fluence was 7.2 J/cm2 for both groups. Patients were evaluated at 3 months after the procedure. RESULTS: A significantly deeper stromal demarcation line was observed in the pulsed group compared to the continuous group (201.11 ± 27.76 vs 159.88 ± 20.86 μm; P < .001). CONCLUSIONS: The pulsed corneal cross-linking protocol induced a significantly deeper stromal demarcation line when compared to the 4 minutes of highly accelerated continuous CXL protocol. Neither CXL protocol induced a shallower demarcation line comparable to less accelerated CXL protocols previously reported. Copyright © SLACK Incorporated.
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