Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Protective Effects of Long-Term Escitalopram Administration on Memory and Hippocampal Bdnf and Bcl-2 Gene Expressions in Rats Exposed to Predictable and Unpredictable Chronic Mild Stress Publisher



Saedi Marghmaleki V1 ; Radahmadi M1 ; Alaei H1 ; Khanahmad H2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Brain Sciences Published:2024


Abstract

Stress and escitalopram (an anti-stress medication) can affect brain functions and related gene expression. This study investigated the protective effects of long-term escitalopram administration on memory, as well as on hippocampal BDNF and BCL-2 gene expressions in rats exposed to predictable and unpredictable chronic mild stress (PCMS and UCMS, respectively). Male rats were randomly assigned to different groups: control (Co), sham (Sh), predictable and unpredictable stress (PSt and USt, respectively; 2 h/day for 21 consecutive days), escitalopram (Esc; 10 mg/kg for 21 days), and predictable and unpredictable stress with escitalopram (PSt-Esc and USt-Esc, respectively). The passive avoidance test was used to assess behavioral variables. The expressions of the BDNF and BCL-2 genes were assessed using real-time quantitative PCR. Latency significantly decreased in the PSt and USt groups. Additionally, latency showed significant improvement in the PSt-Esc group compared to the PSt group. The expression of the BDNF gene significantly decreased only in the USt group. BDNF gene expression significantly increased in the PSt-Esc and USt-Esc groups compared to their respective stress-related groups, whereas the expression of the BCL-2 gene did not change significantly in both PSt-Esc and USt-Esc groups. PCMS and UCMS had devastating effects on memory. Escitalopram improved memory only under PCMS conditions. PCMS and UCMS exhibited fundamental differences in hippocampal BDNF and BCL-2 gene expressions. Furthermore, escitalopram increased hippocampal BDNF gene expression in the PCMS and UCMS subjects. Hence, neurogenesis occurred more significantly than anti-apoptosis under both PCMS and UCMS conditions with escitalopram. © 2024 by the authors.
Related Docs
View other Related Docs
1. The Protective Effects of Escitalopram on Chronic Restraint Stress-Induced Memory Deficits in Adult Rats, Physiology and Pharmacology (Iran) (2022)
2. Effects of Prolonged Escitalopram Administration on Long-Term Potentiation Within the Hippocampal Ca1 Area in Rats Under Predictable and Unpredictable Chronic Mild Stress, Metabolic Brain Disease (2024)
3. The Protective Effects of Escitalopram on Synaptic Plasticity in the Ca1 Region of Chronically Stressed and Non-Stressed Male Rats, International Journal of Developmental Neuroscience (2022)
4. Comparing the Efficacy of Escitalopram With and Without Crocin in Restoring I/O Functions and Ltp Within the Hippocampal Ca1 Region of Stressed Rats, Advanced Biomedical Research (2024)
5. Comparing the Therapeutic Effects of Crocin, Escitalopram and Co-Administration of Escitalopram and Crocin on Learning and Memory in Rats With Stress-Induced Depression, Malaysian Journal of Medical Sciences (2021)
6. Therapeutic Effects of Exercise, Escitalopram and Exercise-Accompanied Escitalopram on Brain Functions in Rats With Depression, Physiology and Pharmacology (Iran) (2022)
7. Therapeutic Effects of Exercise-Accompanied Escitalopram on Synaptic Potency and Long-Term Plasticity in the Hippocampal Ca1 Area in Rats Under Chronic Restraint Stress, Iranian Journal of Basic Medical Sciences (2022)
8. Therapeutic Effects of Saffron Extract on Different Memory Types, Anxiety, and Hippocampal Bdnf and Tnf-Α Gene Expressions in Sub-Chronically Stressed Rats, Nutritional Neuroscience (2022)
Experts (# of related papers)
View all Related Experts
Maryam Radahmadi (40)
Hojatallah Alaei (23)
Other Related Docs
9. Impact of Combined Forced Exercise With Escitalopram on Stress-Induced Depressive-Like Behavior in Male Rats, Journal of Advances in Medical and Biomedical Research (2024)
10. The Protective Effects of Crocin on Input-Output Functions and Long-Term Potentiation of Hippocampal Ca1 Area in Rats Exposed to Chronic Social Isolated Stress, Basic and Clinical Neuroscience (2022)
11. Comparing Various Types of Chronic Psychological Stress on Cognitive Functions and Behaviors in Rats, Basic and Clinical Neuroscience (2024)
12. The Effect of Photoperiodic Stress on Anxiety-Like Behaviors, Learning, Memory, Locomotor Activity and Memory Consolidation in Rats, Physiology and Pharmacology (Iran) (2023)
13. The Effects of Subchronic Social and Isolation Stresses on Learning and Memory Trend in Male Rats, Physiology and Pharmacology (Iran) (2018)
14. The Impact of Crocin and Chronic Isolation Stress on Passive Avoidance Memory and Brain Electrical Activity in Male Rats, Physiology and Pharmacology (Iran) (2022)
15. Effects of Chronic Social Equality and Inequality Conditions on Passive Avoidance Memory and Ptsd-Like Behaviors in Rats Under Chronic Empathic Stress, International Journal of Neuroscience (2024)
16. Effects of Different Dark Chocolate Diets on Memory Functions and Brain Corticosterone Levels in Rats Under Chronic Stress, Physiology and Pharmacology (Iran) (2020)
17. Comparative Evaluation of Antidepressant and Anxiolytic Effects of Escitalopram, Crocin, and Their Combination in Rats, Advanced Biomedical Research (2024)
18. Comparing the Effects of Crocin at Different Doses on Excitability and Long-Term Potentiation in the Ca1 Area, As Well As the Electroencephalogram Responses of Rats Under Chronic Stress, Metabolic Brain Disease (2021)
19. The Effects of Acute, Sub-Chronic and Chronic Psychical Stress on the Brain Electrical Activity in Male Rats, Physiology and Pharmacology (Iran) (2017)
20. Effects of Crocin on Cognitive and Spatial Memories in Rats Under Chronic Isolation Stress, Physiology and Pharmacology (Iran) (2018)
21. Endurance Exercise Improves Avoidance Learning and Spatial Memory, Through Changes in Genes of Gaba and Relaxin-3, in Rats, Biochemical and Biophysical Research Communications (2021)
22. Effects of Aqueous Saffron Extract on Glucoregulation As Well As Hepatic Agt and Tnf‑Α Gene Expression in Rats Subjected to Sub‑Chronic Stress, Advanced Biomedical Research (2023)
23. Effects of Different Timing of Stress on Corticosterone, Bdnf and Memory in Male Rats, Physiology and Behavior (2015)
24. Effects of Acute, Sub-Chronic and Chronic Chocolate Consumption With Different Percent of Cocoa/Sugar on Memory and Eeg Waves in Rats, Physiology and Pharmacology (Iran) (2022)
25. Effects of Stress on Serum and Hippocampal Il-1Β and Glucose Levels As Well As Retention in Rats, Indian Journal of Physiology and Pharmacology (2017)
26. The Impact of Different Dark Chocolate Dietary Patterns on Synaptic Potency and Plasticity in the Hippocampal Ca1 Area of the Rats Under Chronic Isolation Stress, Nutritional Neuroscience (2023)
27. Doxepin Improves Stress-Impaired Long-Term Potentiation and Gene Expression of Bdnf in the Rat Hippocampus, Physiology and Pharmacology (2016)
28. The Role of Cyclooxygenase 2 in the Cognitive Impairment Induced by Alcohol or Stress in Rats, Advanced Biomedical Research (2021)
29. The Effect of Basolateral Amygdala Nucleus Lesion on Memory Under Acute, Mid and Chronic Stress in Male Rats, Turkish Journal of Medical Sciences (2016)
30. Vitamin C Alleviates Neurobehavioral Deficits, Igf1 Expression, and Neuronal Damage Induced by Chronic Social Isolation Stress in the Hippocampus of Adult Male Rats, Proceedings of the National Academy of Sciences India Section B - Biological Sciences (2024)
31. Effects of Chronic Empathic Stress on Synaptic Efficacy, As Well As Short-Term and Long-Term Plasticity at the Schaffer Collateral/Commissural– Ca1 Synapses in the Dorsal Hippocampus of Rats, Metabolic Brain Disease (2025)
32. Effect of Chronic Stress on Short and Long-Term Plasticity in Dentate Gyrus; Study of Recovery and Adaptation, Neuroscience (2014)
33. The Effect of Synchronized Running Activity With Chronic Stress on Passive Avoidance Learning and Body Weight in Rats, International Journal of Preventive Medicine (2013)
34. The Effect of Synchronized Forced Running With Chronic Stress on Short, Mid and Long- Term Memory in Rats, Asian Journal of Sports Medicine (2013)
35. Effect of Different Durations of Stress on Spatial and Cognitive Memory in Male Rats, Journal of Isfahan Medical School (2015)
36. D-Lys-3-Ghrp-6 Impairs Memory Consolidation and Downregulates the Hippocampal Serotonin Ht1a, Ht7 Receptors and Glutamate Glua1 Subunit of Ampa Receptors, Physiology and Behavior (2020)
37. The Effects of Acorus Calamus L. in Preventing Memory Loss, Anxiety, and Oxidative Stress on Lipopolysaccharide-Induced Neuroinflammation Rat Models, International Journal of Preventive Medicine (2018)
38. Effects of Crocin on Locomotor Activity As Well As Novel Object Recognition and Object Location Memories in Chronic Restraint Stressed Rats, Physiology and Pharmacology (Iran) (2020)
39. Investigating the Intervention of Long-Term Aerobic Exercise on the Passive Avoidance Memory in Male Rats, Journal of Isfahan Medical School (2018)
40. Saffron (Crocus Sativus L.) Extract Prevents and Improves D-Galactose and Nano 2 Induced Memory Impairment in Mice, EXCLI Journal (2012)
41. The Dose-Dependent Neuroprotective Effect of Norepinephrine in Improving Memory Retrieval in an Experimental Model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Brain Research Bulletin (2024)
42. Effect of Forced Treadmill Exercise on Stimulation of Bdnf Expression, Depression Symptoms, Tactile Memory and Working Memory in Lps-Treated Rats, Behavioural Brain Research (2022)
43. Preventive Effects of Fixed and Progressive Forced Exercises on Memory and Brain Electrical Activity in Morphine-Addicted Rats, Anais da Academia Brasileira de Ciencias (2022)
44. The Effects of Doxepin on Stress-Induced Learning, Memory Impairments, and Tnf-A Level in the Rat Hippocampus, Research in Pharmaceutical Sciences (2015)
45. In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats, Brain Research (2023)
46. Preventive and Therapeutic Effect of Treadmill Running on Chronic Stress-Induced Memory Deficit in Rats, Journal of Bodywork and Movement Therapies (2015)
47. Comparative Study of the Protective Effects of Crocin and Exercise on Long-Term Potentiation of Ca1 in Rats Under Chronic Unpredictable Stress, Life Sciences (2020)
48. The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal Memory Mediators in Stressed Rats, Malaysian Journal of Medical Sciences (2016)
49. Effects of Doxepin on Gene Expressions of Bcl-2 Family, Tnf-Α, Map Kinase 14, and Akt1 in the Hippocampus of Rats Exposed to Stress, Research in Pharmaceutical Sciences (2017)
50. Long-Term Decreases in the Expression of Calcineurin and Gabaa Receptors Induced by Early Maternal Separation Are Associated With Increased Anxiety-Like Behavior in Adult Male Rats, Developmental Neuroscience (2021)