Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]

Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos] Publisher Pubmed

Haddadi H¹ ; Rajaei Z¹ ; Alaei H¹ ; Shahidani S¹

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1. Isfahan University of Medical Sciences, School of Medicine, Department of Physiology, Isfahan, Iran

Source: Arquivos de Neuro-Psiquiatria Published:2018

Abstract

The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson’s disease.The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson’s disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson’s disease patients. © 2018, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.

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Style	Citing Format
MLA	Haddadi H, et al.. "Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]." Arquivos de Neuro-Psiquiatria, vol. 76, no. 2, 2018, pp. 71-77.
APA	Haddadi H, Rajaei Z, Alaei H, Shahidani S (2018). Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]. Arquivos de Neuro-Psiquiatria, 76(2), 71-77.
Chicago	Haddadi H, Rajaei Z, Alaei H, Shahidani S. "Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]." Arquivos de Neuro-Psiquiatria 76, no. 2 (2018): 71-77.
Harvard	Haddadi H et al. (2018) 'Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]', Arquivos de Neuro-Psiquiatria, 76(2), pp. 71-77.
Vancouver	Haddadi H, Rajaei Z, Alaei H, Shahidani S. Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]. Arquivos de Neuro-Psiquiatria. 2018;76(2):71-77.
BibTex	@article{ author = {Haddadi H and Rajaei Z and Alaei H and Shahidani S}, title = {Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos]}, journal = {Arquivos de Neuro-Psiquiatria}, volume = {76}, number = {2}, pages = {71-77}, year = {2018} }
RIS	TY - JOUR AU - Haddadi H AU - Rajaei Z AU - Alaei H AU - Shahidani S TI - Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos] JO - Arquivos de Neuro-Psiquiatria VL - 76 IS - 2 SP - 71 EP - 77 PY - 2018 ER -

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