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The Effects of Crocin on 6-Ohda-Induced Oxidative/Nitrosative Damage and Motor Behaviour in Hemiparkinsonian Rats Publisher



Hosseini M1 ; Rajaei Z1, 2 ; Alaei H3 ; Tajadini M4
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Malaysian Journal of Medical Sciences Published:2016


Abstract

Background: Crocin is considered to prevent oxidative stress-related diseases, such as ischemia and Alzheimer’s. The aim of the present investigation was to evaluate the effects of crocin on motor behaviour and 6-OHDA-induced oxidative/nitrosative damage to the striatum in an experimental model of Parkinson’s disease. Methods: Left medial forebrain bundle was lesioned by microinjection of 6-OHDA (16μg in 0.2% ascorbate-saline). Crocin (30 and 60 mg/kg) was injected intraperitoneally three days before surgery until six weeks. Rotational behaviour and biochemical analysis were used to evaluate the effect of crocin in a unilateral 6-OHDA-induced model of Parkinson's disease. Results: The contralateral rotations induced by apomorphine in 6-OHDA lesioned group were highly significant (P < 0.001) as compared to the sham group. Moreover, chronic administration of crocin at doses of 30 and 60 mg/kg over six weeks did not change the rotations. The TBARS and nitrite levels in the striatum were also significantly (P < 0.05) increased in lesioned group. Treatment with crocin at a dose of 60 mg/kg significantly decreased the nitrite levels (P < 0.05) in the striatum. Conclusion: Crocin at a dose of 60 mg/kg could be effective in preventing the nitrosative damage in the striatum. Further investigations using higher doses of crocin is suggested to get the full neuroprotective effects of crocin in Parkinson’s disease. © Penerbit Universiti Sains Malaysia, 2016.
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