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Comparison of Troponin, High-Sensitivity Troponin, and Copeptin Markers at Different Times in Patients With High-Risk Chest Pain Publisher



Abootalebighahnavieh A1 ; Mirhosseini SM2 ; Sajjadiehkhajouei A3 ; Moayednia R4 ; Jahromidastjerdi M5
Authors
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Authors Affiliations
  1. 1. Department of Emergency Medicine, School of Medicine, Emergency Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pathology, School of Medicine, Clinical Medical Laboratory, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2019


Abstract

Background: The incidence of cases with acute myocardial infarction (AMI) and patients suffering from chest pain (CP) referred to emergency departments are increasing. Therefore, finding a marker that can help faster diagnose of the disease can have beneficial effects for patients. This study compared troponin, high-sensitivity troponin, and copeptin markers at different times in patients with high-risk chest pain. Methods: This study was performed on 90 emergency care patients with high-risk chest pain, as the first symptom of myocardial infarction (MI), in educational hospitals in Isfahan City, Iran. Demographic and clinical data including the levels of troponin, high-Sensitivity troponin, and copeptin markers were collected and evaluated at the time of arrival, and 2 and 6 hours later. Findings: The mean age of patients with high-risk chest pain was 60.73 ± 1.23 years, of which 57 (63.3%) were men. There were significant differences between the frequency of three markers at arrival (P = 0.0004) and 2 hours (P = 0.0009) later. Nevertheless, after 6 hours, the results did not show any significant difference (P > 0.0010). Conclusion: Repeated measurement of copeptin leads to a more successful AMI prevention compared to troponin and high-sensitivity troponin markers. © 2019 Isfahan University of Medical Sciences(IUMS). All rights reserved.
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