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Hard Tissue Reaction to Mineral Trioxide Aggregate and Experimental Root-End Filling Material in Guinea Pig Mandibles Publisher



Akhavan A1 ; Parashos P2 ; Razavi SM3 ; Davoudi A4 ; Shadmehr E1, 5
Authors
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Authors Affiliations
  1. 1. Torabinejad Dental Materials Research Center and Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Melbourne Dental School, University of Melbourne, Melbourne, VIC, Australia
  3. 3. Dental Implants Research Center and Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Dental Implants Research Center and Resident of Prosthodontics, Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Postgraduate Endodontic Resident, UB Dental School, Buffalo, NY, United States

Source: Journal of Dental Sciences Published:2017


Abstract

Background/purpose Root-end filling materials are used to fill and seal the root apex during periradicular surgery. Mineral trioxide aggregate (MTA) is a widely-used material because of its particular characteristics. Cold ceramic (CC) is an experimental material that has been recently introduced. The purpose of this study was to compare bone tissue response to CC and MTA in an animal model. Materials and methods Forty-five male guinea pigs (weighing 750–850 g) were anesthetized with 10 mg/kg ketamine HCL and 12 mg/kg xylazine. A triangular incision of around 15 mm was prepared in the posterior site along the symphysis in both right and left sides of the mandible. A 3 mm × 3 mm diameter cylindrical hole was prepared in each side using a trephine. Two Teflon cylindrical tube applicators were filled with white MTA and CC and inserted into the defects separately. Histopathological evaluation of the specimens was completed after 2 weeks and 12 weeks. The extent of inflammation was recorded and analyzed using the Mann–Whitney U test and SPSS software version 12 at a significance level of 0.05. Results MTA and CC produced moderate and mild hard tissue responses respectively after 2 weeks and 12 weeks. No significant differences were found in the distribution of the responses between the two groups at either time point. Conclusion Both CC and MTA demonstrated biocompatibility with minor adverse impact on hard tissue and healing recovery after 12 weeks. © 2017 Association for Dental Sciences of the Republic of China
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