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Histologic, Histomorphometric, and Osteogenesis Comparative Study of a Novel Fabricated Nanocomposite Membrane Versus Cytoplast Membrane Publisher Pubmed



Haghighat A1 ; Shakeri S2 ; Mehdikhani M3 ; Dehnavi SS4 ; Talebi A5
Authors
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Authors Affiliations
  1. 1. Associate Professor, Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Resident of Oral and Maxillofacial Surgery, Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Assistant Professor, Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  4. 4. Master of Science, Department of New Science and Technology Campus (Biomaterial Group), Semnan University, Semnan, Iran
  5. 5. Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Oral and Maxillofacial Surgery Published:2019


Abstract

Purpose: The present study compared the in vivo efficacy of a novel synthesized polycaprolactone (PCL)/polyethylene glycol (PEG)/bioactive glass (BG) nanocomposite membrane versus a cytoplast (Cy) membrane in terms of the average percentage of new bone formation and inflammation levels. Materials and Methods: In the present interventional animal study, 12 male New Zealand rabbits were tested. In the parietal bone of the rabbits, 24 defects were prepared (2 defects for each rabbit), which were divided into 3 equal groups (Cy, PCL, and control). Each rabbit's calvarial bone was prepared for the histologic and histomorphometric survey. The amount of regenerated bone (ie, length, area, percentage), necrosis rate, fibrosis (fibrosis plus and percentage), and inflammation in the standard defects of parietal bone in the rabbits were examined and compared after 10 weeks. Results: A significant difference was found between the Cy and PCL groups regarding the mean area and thickness of the bone. We also found a significant difference in the bone length, area, and percentage formed between PCL and control groups. Also, the rate of fibrous tissue formation was significantly different statistically between the PCL and control groups. The results showed the influence of the PCL membrane in generating more bone and less fibrous tissue. In all 3 groups, negligible inflammation and no necrosis was observed. Conclusions: The results of the present study have shown that combining PCL, PEG, and BGs could be promising for bone regeneration in jaw defects, around dental implants, and in oral and maxillofacial defects. © 2019 American Association of Oral and Maxillofacial Surgeons
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