Isfahan University of Medical Sciences

Science Communicator Platform

Share By
Association Between Dietary Intake, Profibrotic Markers, and Blood Pressure in Patients With Chronic Kidney Disease Publisher

Summary: Higher insoluble fiber intake may lower MMP-2 levels in CKD patients, while molybdenum intake correlates with DBP. More research is needed to confirm. #KidneyHealth #DietaryFiber

Mohtashamian A ; Soleimani A ; Reza Gilasi HR ; Kheiripour N ; Taba SMM ; Sharifi N
Authors

Source: Advanced Biomedical Research Published:2024


Abstract

Background: Among profibrotic and oxidant factors, matrix metalloproteinases (MMPs) and advanced glycation end products (AGEs) have a major impact on the progression of chronic kidney disease (CKD). However, very limited studies evaluated the relationships between nutrient intake and the mentioned factors in patients with CKD. Therefore, the present study aimed to investigate the correlation between dietary intake and the levels of MMPs, AGEs, and blood pressure (BP) in these patients. Materials and Methods: This cross‑sectional study was performed on 90 patients with CKD (stages 2–5). To evaluate the dietary intake of patients, three days of 24‑hour food recall were completed through face‑to‑face and telephone interviews. Measurement of MMP‑2 and MMP‑9 concentration was done by enzyme‑linked immunosorbent assay. The fluorimetric technique was used to measure the total serum AGEs. Results: The patients’ average dietary intake of sodium, potassium, phosphorus, energy, and protein was 725 mg/day, 1600 mg/day, 703 mg/day, 1825 kcal/day, and 64.83 g/day, respectively. After adjustment of confounding variables, a significant inverse relationship was observed between dietary intake of insoluble fiber and serum levels of MMP‑2 (β = ‑0.218, P = 0.05). In addition, a significant positive relationship was found between molybdenum (Mo) intake and diastolic BP (β =0.229, P = 0.036). Conclusion: A higher intake of insoluble fiber might be associated with lower serum levels of MMP‑2. Also, a higher Mo intake can be correlated to a higher DBP in patients with CKD. It is suggested to conduct future studies with longitudinal designs and among various populations to better elucidate the observed relationships. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Low Protein Diet Score: A Novel Diet Quality Index and Predictor of Disease Progression in Patients With Chronic Kidney Disease, Progress in Nutrition (2018)
2. Association of Dietary Acid Load With Cardiovascular Disease Risk Factors in Patients With Diabetic Nephropathy, Nutrition (2015)
3. Association of Dietary Minerals and Phosphorus to Protein Ratio With Quality of Life in Iranian Hemodialysis Patients: A Cross-Sectional Study, Scientific Reports (2025)
Experts (# of related papers)
View all Related Experts
Awat Feizi (6)
Mohammad Hossein Rouhani (6)
Association Between Dietary Intake, Profibrotic Markers, and Blood Pressure in Patients With Chronic Kidney Disease
Other Related Docs
4. Association Between Adherence to the Mediterranean Diet and Renal Function Biomarkers and Cardiovascular Risk Factors Among Diabetic Patients With Nephropathy, Clinical Nutrition ESPEN (2020)
5. Direct Association Between High Fat Dietary Pattern and Risk of Being in the Higher Stages of Chronic Kidney Disease, International Journal for Vitamin and Nutrition Research (2019)
6. Dietary Total, Plant, and Animal Protein Intake in Relation to Cardiovascular Outcomes and Inflammatory Factors in Elderly Men: A Cross-Sectional Study, Food Science and Nutrition (2024)
7. The Association Between Plant and Animal Protein Intake and Quality of Life in Patients Undergoing Hemodialysis, Frontiers in Nutrition (2023)
8. Dietary Inflammatory Index and Its Association With Renal Function and Progression of Chronic Kidney Disease, Clinical Nutrition ESPEN (2019)
9. Comparison of Three Diet Quality Indices for Patients With Chronic Kidney Disease, Archives of Iranian Medicine (2017)
10. Magnesium Intake, Insulin Resistance and Markers of Endothelial Function Among Women, Public Health Nutrition (2021)
11. Dietary Acid Load and Risk of Type 2 Diabetes Mellitus: A Case–Control Study, Clinical Nutrition ESPEN (2022)
12. Association of Major Dietary Patterns With Advanced Glycation End Products and High-Sensitivity C-Reactive Protein in People With Type 1 Diabetes Mellitus, Nutrition Journal (2023)
13. Moderate Replacement of Carbohydrates by Dietary Fats Affects Features of Metabolic Syndrome: A Randomized Crossover Clinical Trial, Nutrition (2014)
14. The Effect of Fenugreek Seed Supplementation on Serum Irisin Levels, Blood Pressure, and Liver and Kidney Function in Patients With Type 2 Diabetes Mellitus: A Parallel Randomized Clinical Trial, Complementary Therapies in Medicine (2020)
15. Usual Energy and Macronutrient Intakes in a Large Sample of Iranian Middle-Aged and Elderly Populations, Nutrition and Dietetics (2019)
16. Effect of Substituting Saturated With Monounsaturated Fatty Acids on Serum Visfatin Levels and Insulin Resistance in Overweight Women: A Randomized Cross-Over Clinical Trial, International Journal of Food Sciences and Nutrition (2012)
17. Adherence to Dietary Approaches to Stop Hypertension (Dash) and Mediterranean Dietary Patterns in Relation to Cardiovascular Risk Factors in Older Adults, Clinical Nutrition ESPEN (2020)
18. Association Between the Index of Nutritional Quality and Lipid Profile in Adult Women, Endocrinology, Diabetes and Metabolism (2022)
19. Do Patterns of Nutrient Intake Predict Self-Reported Anxiety, Depression and Psychological Distress in Adults? Sepahan Study, Clinical Nutrition (2019)
20. Assessment of the Distribution of Usual Intake of Nutrients and Estimating Prevalence of Intake Deficiency and Excess in a General Over 40-Years of Age Population of Central Region of Iran: Application of the National Cancer Institute (Nci) Method, Journal of Isfahan Medical School (2013)