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The Effect of Fenugreek Seed Supplementation on Serum Irisin Levels, Blood Pressure, and Liver and Kidney Function in Patients With Type 2 Diabetes Mellitus: A Parallel Randomized Clinical Trial Publisher Pubmed



Hadi A1 ; Arab A2 ; Hajianfar H3 ; Talaei B4, 5 ; Miraghajani M6, 7 ; Babajafari S8 ; Marx W9 ; Tavakoly R8, 10
Authors
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Authors Affiliations
  1. 1. Halal Research Center of IRI, FDA, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Department of Nutrition, School of Health, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. The Early Life Research Unit, Academic Division of Child Health, Obstetrics and Gynaecology and Nottingham Digestive Disease Centre and Biomedical Research Centre, The School of Medicine, University of Nottingham, Nottingham, NG7 2UH, United Kingdom
  8. 8. Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Deakin University, iMPACT, School of Medicine, Geelong, Australia
  10. 10. Student Research Committee, School of Health, Kerman University of Medical Sciences, Kerman, Iran

Source: Complementary Therapies in Medicine Published:2020


Abstract

Objectives: This study was designed to determine the effects of fenugreek seed (FS) on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus (T2DM). Methods: In an 8-week randomized controlled clinical trial, T2DM patients (n = 50) were assigned to the intervention (5 g FS powder, 3 times a day) or control group. Both groups received anti-diabetic drugs and nutritional consults. Serum samples were collected and blood pressure was measured at baseline and end of the trial. Data on dietary intake and physical activity was determined using the questionnaires. Results: Compared to the control group, FS consumption resulted in a significant decrease in fasting plasma glucose (FPG) (p = 0.024), as well as a significant change in serum alanine aminotransferase (ALT) (p = 0.02) and alkaline phosphatase (ALP) (p = 0.001). Within-group analysis showed a significant decrease in aspartate aminotransferase (AST) (p = 0.014), systolic blood pressure (SBP) (p = 0.001), and irisin (p = 0.001) in the FS group, and a significant increase in creatinine (Cr) (p = 0.001) and decrease in estimated glomerular filtration rate (eGFR) (p = 0.001) in the control group. FS consumption did not have any significant effect on diastolic blood pressure (DBP) and blood urea nitrogen (BUN). Conclusion: FS intake has some beneficial effects on FPG, SBP, and some liver and kidney function tests in patients with T2DM. Further studies are required to investigate the effect of FS on irisin levels. Trial registration number http://www.irct.ir, code: IRCT20190618043924N1 © 2020 Elsevier Ltd
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