Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Can Urine Protein to Creatinin Ratio Predict the Severity of Coronary Artery Disease?



Honarbakhsh S1 ; Sadeghi M2 ; Sanei H1 ; Rabiei K3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Cardiovascular Research Center, Cox Research Group, Poursina Hakim Research Institution, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2009

Abstract

Background: Albuminuria is one of the abnormalities which occur in diabetics. Different studies have shown its relationship with cardiovascular diseases but few studies have been performed to show the relationship between albuminoria level and coronary artery disease (CAD) severity. This study was designed to asses the relationship between albuminuria and coronary artery disease severity. Methods: In this cross-sectional study, the 164 Non-Insulin Dependent Diabetes Mellitus patients with angina pectoris who hospitalized for diagnostic or therapeutic angiography in Isfahan Chamran hospital were included. Urine Pr/Cr ratio has been calculated in all patients, using the first sample of morning urine. The standard angiography video has been assessed by three cardiologists through Seldinger method. CAD score has been given from 0 to 21 based on Extent method. The relationship between CAD severity and urine Pr/Cr ratio has been assessed with bivariate correlation methods and multivariate analysis. Findings: In 164 patients (males = 80 & females = 84) morning urine protein mean was 22.77 ± 30.99 and morning urine creatinin mean was 0.07 ± 0.04. Urine Pr/Cr ratio was 760.94 ± 401.56 mg/g and its median was 181.02. The CAD score was equal to 13.34 ± 6.24. There was no correlation between urine Pr/Cr ratio and CAD severity (P = 0.778, r = 0.022). In multivariate analysis, increased urine Pr/Cr ratio led to increased CAD severity by control of the age, FBS, gender, Captopril use, history of HTN and hyperlipidemia variables (P = 0.021). Conclusion: The amount of albuminuria which measured based on morning urine sample Pr/Cr ratio may be an independent risk factor for severity of CAD and can predict it. These findings signify the importance of albuminuria diagnosis and treatment. © 2009, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Incidence of Microalbuminuria and Its Associated Risk Factors in Type 2 Diabetic Patients in Isfahan, Iran, Review of Diabetic Studies (2007)
2. Body Mass Index or Microalbuminuria, Which One Is More Important for the Prediction and Prevention of Diastolic Dysfunction in Non-Diabetic Hypertensive Patients?, International Journal of Preventive Medicine (2012)
3. Incidence of Microalbuminuria and Associated Risk Factors in Type 2 Diabetes Mellitus, Iranian Journal of Diabetes and Lipid Disorders (2006)
4. Why 24-H Urine Albumin Excretion Rate Method Still Is Used for Screening of Diabetic Nephropathy in Isfahan Laboratories?, International Journal of Preventive Medicine (2014)
5. Factors Associated With Serum Albumin in Diabetes Mellitus Type 2 With Microalbuminuria Using Non-Normal Mixed Models: A Prospective Cohort Study, Iranian Red Crescent Medical Journal (2016)
6. Prediction of Coronary Atherosclerotic Disease With Liver Transaminase Level, Liver International (2007)
7. Uric Acid: A Risk Factor for Coronary Atherosclerosis?, Cardiovascular Journal of South Africa (2007)
8. Comparison of Urinary N-Acetyl-Beta-D-Glucosaminidase in Non-Diabetic Subjects and Type2 Diabetic Patients, Iranian Journal of Endocrinology and Metabolism (2011)
Experts (# of related papers)
View all Related Experts
Shahrzad Shahidi (7)
Bijan Iraj (4)
Other Related Docs
9. Effect of Sitagliptin on Proteinuria in Patients With Type 2 Diabetes-A Renoprotective Effect of Sitagliptin, Journal of Research in Medical Sciences (2021)
10. Is Subcutaneous Fat Tissue Associated With Coronary Artery Disease?, Iranian Journal of Endocrinology and Metabolism (2012)
11. The Protein-Creatinine Ratio in Spot Morning Urine Samples and 24-H Urinary Protein Excretion in Patients With Systemic Lupus Erythematosus, Rheumatology International (2009)
12. Does Metabolic Syndrome Increase Contrast‑Induced Nephropathy in Patients With Normal Renal Function?, Journal of Research in Medical Sciences (2024)
13. Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?, Acta Medica Iranica (2008)
14. Effect of Angiotensin Receptor Inhibitors on Endothelial Dysfunction Indices in Patients With Diabetic Nephropathy, Journal of Isfahan Medical School (2011)
15. Epicardial Fat Thickness and Severity of Coronary Heart Disease in Patients With Diabetes Mellitus Type Ii, ARYA Atherosclerosis (2018)
16. Serum Uric Acid Level and Its Association With Cardiometabolic Risk Factors in Prediabetic Subjects, Journal of Research in Medical Sciences (2014)
17. Reduction of Proteinuria by Pioglitazone in Patients With Non-Diabetic Renal Disease, Journal of Research in Medical Sciences (2011)
18. Urine Albumin to Creatinine Ratio and Echocardiographic Left Ventricular Structure and Function in Patients With Essential Hypertension, American Heart Hospital Journal (2011)
19. The Relationship Between Random Urinary Protein-To-Creatinine Ratio and 24-Hours Urine Protein in Diagnosis of Proteinuria in Mild Preeclampsia, Journal of Research in Medical Sciences (2006)
20. Relationship Between Metabolic Syndrome and Angiographic Severity of Coronary Artery Disease, ARYA Atherosclerosis (2016)
21. The Potential of Cardiac Biomarkers, Nt-Probnp and Troponin T, in Predicting the Progression of Nephropathy in Diabetic Patients: A Meta‐Analysis of Prospective Cohort Studies, Diabetes Research and Clinical Practice (2023)
22. Comparing the Urinary Value of N-Acetyl-Β-D-Glucosaminidase (Nag) and Β2-Microglobulinuria (Β2m) in Acute Kidney Damage in Children, Journal of Isfahan Medical School (2013)
23. The Protein Creatinine Ratio in Spot Morning Urine Samples and 24 Hour Urinary Protein Excretion in Patients With Systemic Lupus Erythematosus, Journal of Isfahan Medical School (2008)
24. A Workshop on Urinalysis and a Survey on Urine Microscopy Among Kidney Centers of Iran, Iranian Journal of Kidney Diseases (2013)
25. Epidemiologic Evaluation of Demographic and Basic Clinical Factors in Patients With Chronic Kidney Disease in Isfahan City, Iran, During 1996-2011, Journal of Isfahan Medical School (2017)
26. Association of Serum Uric Acid With Level of Blood Pressure in Type 2 Diabetic Patients, Iranian Journal of Kidney Diseases (2014)
27. Effect of Allopurinol in Decreasing Proteinuria in Type 2 Diabetic Patients, Iranian Journal of Kidney Diseases (2010)
28. Allopourinol Effect on Reducing Proteinuria in Diabetic Retinopathy, Journal of Isfahan Medical School (2010)
29. Coronary Heart Disease in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors, Acta Cardiologica (2006)
30. Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial, International Journal of Nephrology (2015)
31. Coronary Artery Calcification Score As the Determinant of Coronary Artery Disease in Chronic Kidney Disease Patients: A Preliminary Study, ARYA Atherosclerosis (2024)
32. Association of Serum Uric Acid With Proteinuria in Type 2 Diabetic Patients, Journal of Research in Medical Sciences (2013)
33. The Effect of Linagliptin on Microalbuminuria in Patients With Diabetic Nephropathy: A Randomized, Double Blinded Clinical Trial, Scientific Reports (2023)
34. The Effects of Blocking Angiotensin Receptors on Early Stages of Diabetic Nephropathy, International Journal of Preventive Medicine (2012)
35. Association Between Salt Intake and Albuminuria in Normotensive and Hypertensive Individuals, International Journal of Hypertension (2013)
36. Is High Preprocedural Renal Resistive Index Sensitive Enough to Predict Iodine Contrast-Induced Nephropathy in Patients Receiving Intra-Arterial Iodinate Contrast?, Current Problems in Diagnostic Radiology (2021)
37. Effect of Pioglitazone on Proteinuria in Non-Diabetic Renal Patients: A Self-Control Clinical Trial, Journal of Isfahan Medical School (2010)
38. The Relation Between Ankle-Brachial Index (Abi) and Coronary Artery Disease Severity and Risk Factors: An Angiographic Study, ARYA Atherosclerosis (2011)
39. The Renoprotective Effect of Linagliptin in Type 2 Diabetic Patients With Severely Increased Albuminuria, Iranian Journal of Kidney Diseases (2021)