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The Trend of Atherogenic Indices in Patients With Type 2 Diabetes After Bariatric Surgery: A National Cohort Study Publisher Pubmed



Seyedi A1 ; Rabizadeh S1 ; Abbaspour F2 ; Karimpour Reyhan S1 ; Asgari Soran N1 ; Nabipoor A1, 3 ; Yadegar A1 ; Mohammadi F1 ; Hashemi R1 ; Qahremani R1 ; Saffari E4 ; Riazi S5 ; Sarv F5 ; Nakhjavani M1 Show All Authors
Authors
  1. Seyedi A1
  2. Rabizadeh S1
  3. Abbaspour F2
  4. Karimpour Reyhan S1
  5. Asgari Soran N1
  6. Nabipoor A1, 3
  7. Yadegar A1
  8. Mohammadi F1
  9. Hashemi R1
  10. Qahremani R1
  11. Saffari E4
  12. Riazi S5
  13. Sarv F5
  14. Nakhjavani M1
  15. Pazouki A5
  16. Esteghamati A1

Source: Surgery for Obesity and Related Diseases Published:2025


Abstract

Background: Bariatric surgery has profound effects on weight loss, metabolic regulation, and gut hormone modulation, which make it an efficient tool for managing obesity and improving diabetes outcomes. Objectives: The objective of this study is to evaluate the atherogenic indices, including atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli's risk index II (CRI-II), and lipoprotein combine index (LCI) in individuals with type 2 diabetes (T2D) living with excess weight, who have undergone bariatric surgery. Setting: Three types of surgery including one-anastomosis gastric bypass/mini gastric bypass (OAGB/MGB), sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) were performed on patients with obesity and T2D in the period of August 2009 to February 2021 at the Surgical Department of Hazrat-e Rasool Hospital (University Hospital), Tehran, Iran. Methods: In this retrospective cohort, 1246 individuals with obesity and T2D who underwent 3 types of bariatric surgery including RYGB, SG, and OAGB/MGB were studied for 2 years after the surgery; the data were derived from the National Iranian Obesity Surgery Database. Afterward, the trend of biochemical parameters, total weight loss (TWL%), and atherogenesis-related indices were evaluated from baseline up to 2 years in 5 follow-up visits. Results: A total of 1246 patients with T2D and obesity who underwent bariatric surgery were included in this study. The trend of all atherogenesis-related indices, including AIP, LCI, CRI-II, and AC, showed a significant reduction (49.2%, 53.4%, 20.8%, 22%, respectively) 2 years after the bariatric surgery (P < .05). In the 6-month follow-up, 1-year follow-up, and 2-year follow-up, 1023 (83.10%), 719 (57.70%), and 341 (27.36%) individuals participated, respectively. In addition, a significant increase in high-density lipoprotein cholesterol levels was observed 2 years after the surgery in both sexes (P < .05). Conclusions: The bariatric surgery significantly reduced the levels of atherogenic indices including AIP, CRI-II, LCI, and AC. © 2025
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