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The Trend of Atherogenic Indices in Patients With Type 2 Diabetes After Bariatric Surgery: A National Cohort Study Publisher Pubmed



Seyedi A1 ; Rabizadeh S1 ; Abbaspour F2 ; Karimpour Reyhan S1 ; Asgari Soran N1 ; Nabipoor A1, 3 ; Yadegar A1 ; Mohammadi F1 ; Hashemi R1 ; Qahremani R1 ; Saffari E4 ; Riazi S5 ; Sarv F5 ; Nakhjavani M1 Show All Authors
Authors
  1. Seyedi A1
  2. Rabizadeh S1
  3. Abbaspour F2
  4. Karimpour Reyhan S1
  5. Asgari Soran N1
  6. Nabipoor A1, 3
  7. Yadegar A1
  8. Mohammadi F1
  9. Hashemi R1
  10. Qahremani R1
  11. Saffari E4
  12. Riazi S5
  13. Sarv F5
  14. Nakhjavani M1
  15. Pazouki A5
  16. Esteghamati A1
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Science, Tehran, Iran
  3. 3. Cardiothoracic Imaging Section, Department of Radiology, University of Washington, Seattle, WA, United States
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Rasoule-Akram Hospital, Tehran, Iran

Source: Surgery for Obesity and Related Diseases Published:2025


Abstract

Background: Bariatric surgery has profound effects on weight loss, metabolic regulation, and gut hormone modulation, which make it an efficient tool for managing obesity and improving diabetes outcomes. Objectives: The objective of this study is to evaluate the atherogenic indices, including atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli's risk index II (CRI-II), and lipoprotein combine index (LCI) in individuals with type 2 diabetes (T2D) living with excess weight, who have undergone bariatric surgery. Setting: Three types of surgery including one-anastomosis gastric bypass/mini gastric bypass (OAGB/MGB), sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) were performed on patients with obesity and T2D in the period of August 2009 to February 2021 at the Surgical Department of Hazrat-e Rasool Hospital (University Hospital), Tehran, Iran. Methods: In this retrospective cohort, 1246 individuals with obesity and T2D who underwent 3 types of bariatric surgery including RYGB, SG, and OAGB/MGB were studied for 2 years after the surgery; the data were derived from the National Iranian Obesity Surgery Database. Afterward, the trend of biochemical parameters, total weight loss (TWL%), and atherogenesis-related indices were evaluated from baseline up to 2 years in 5 follow-up visits. Results: A total of 1246 patients with T2D and obesity who underwent bariatric surgery were included in this study. The trend of all atherogenesis-related indices, including AIP, LCI, CRI-II, and AC, showed a significant reduction (49.2%, 53.4%, 20.8%, 22%, respectively) 2 years after the bariatric surgery (P < .05). In the 6-month follow-up, 1-year follow-up, and 2-year follow-up, 1023 (83.10%), 719 (57.70%), and 341 (27.36%) individuals participated, respectively. In addition, a significant increase in high-density lipoprotein cholesterol levels was observed 2 years after the surgery in both sexes (P < .05). Conclusions: The bariatric surgery significantly reduced the levels of atherogenic indices including AIP, CRI-II, LCI, and AC. © 2025
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