Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Advances in Microfluidic Technologies for Antibody Separation and Detection: Toward Enhanced Diagnostics and Therapeutic Applications Publisher



S Keshavarz Sina MOHAMMADMAHDI ; Mj Inanlu Mohammad J ; K Omidfar KOBRA ; V Bazargan VAHID
Authors

Source: Microchemical Journal Published:2025


Abstract

The rapidly advancing field of microfluidics has significantly transformed diagnostics and pharmaceutical industries by enabling precise control and analysis of fluids at the microscale. This review examines recent advancements in microfluidic technologies specifically tailored for antibody separation and detection, highlighting their impact in immunodiagnostics and therapeutic antibody manufacturing. Key methodologies discussed include microfluidic ELISAs, biosensors, and immunoaffinity-based techniques, each demonstrating distinct strengths such as enhanced sensitivity, rapid processing, and reduced reagent usage. These platforms facilitate point-of-care (PoC) diagnostics, high-throughput drug screening, and personalized medicine, addressing limitations of conventional diagnostic methods related to sample volume, processing time, and laboratory infrastructure requirements. Additionally, the review addresses commercialization challenges, including scalability, standardization, and regulatory approval, and explores successful strategies employed by market-ready microfluidic devices. This analysis provides valuable insights for researchers and industry professionals aiming to leverage microfluidics to enhance diagnostic accuracy, therapeutic efficacy, and healthcare accessibility. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Biomedical Applications of Microfluidic Devices, Biomedical Applications of Microfluidic Devices (2020)
2. Microfluidic Technologies Using Oral Factors: Saliva-Based Studies, Applications of Biomedical Engineering in Dentistry (2019)
3. Microfluidics: Organ-On-A-Chip, Biomedical Applications of Microfluidic Devices (2020)
Experts (# of related papers)
View all Related Experts
Kobra Omidfar (2)
Nima Rezaei (1)
Other Related Docs
4. Recent Advances of Utilizing Artificial Intelligence in Lab on a Chip for Diagnosis and Treatment, Small (2022)
5. Multiple Functions of Microfluidic Platforms: Characterization and Applications in Tissue Engineering and Diagnosis of Cancer, Electrophoresis (2020)
6. A Mini Review on Recent Progress of Microfluidic Systems for Antibody Development, Journal of Diabetes and Metabolic Disorders (2024)
7. A Review of Biomaterials for Developing High-Performance Immunosensors: Rigid and Flexible Platforms, TrAC - Trends in Analytical Chemistry (2025)
8. Wearable Microfluidic Immunosensors for Point-Of-Care Detection of Bio-Analytes: A Critical Review, Journal of Materials Chemistry B (2025)
9. Design Principles of Paper-Based Sensors, (2024)
10. Microfluidic Devices for Pathogen Detection, Biomedical Applications of Microfluidic Devices (2020)
11. Nanotechnology-Assisted Microfluidic Systems: From Bench to Bedside, Nanomedicine (2021)
12. A Micropillar Array-Based Microfluidic Chip for Label-Free Separation of Circulating Tumor Cells: The Best Micropillar Geometry?, Journal of Advanced Research (2023)
13. An Overview of Microfluidic Devices, Biomedical Applications of Microfluidic Devices (2020)
14. Microfluidics in the Diagnosis, Treatment, and Drug Delivery of Chronic Respiratory Disorders: Advancements and Potential Applications, (2024)
15. Role of Nanofluids in Drug Delivery and Biomedical Technology: Methods and Applications, Nanotechnology# Science and Applications (2020)
16. Rapid Prototyping of Microfluidic Chips Using Laser-Cut Double-Sided Tape for Electrochemical Biosensors, Journal of the Brazilian Society of Mechanical Sciences and Engineering (2017)
17. Microfluidic System Consisting of a Magnetic 3D-Printed Microchannel Filter for Isolation and Enrichment of Circulating Tumor Cells Targeted by Anti-Her2/Mof@Ferrite Core-Shell Nanostructures: A Theranostic Ctc Dialysis System, Analytical Chemistry (2024)
18. Controllable Size and Form of Droplets in Microfluidic-Assisted Devices: Effects of Channel Geometry and Fluid Velocity on Droplet Size, Materials Science and Engineering C (2020)
19. Label-Free Isolation of Circulating Tumor Cells Using Negative Lateral Dielectrophoresis-Assisted Inertial Microfluidics, Microfluidics and Nanofluidics (2023)
20. Microfluidic Devices for Detection of Rna Viruses, Reviews in Medical Virology (2021)