Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus

Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus Publisher

Larijani B¹ ; Heshmat R² ; Ebrahimirad M³ ; Khatami S³ ; Valadbeigi S³ ; Saghiri R³

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1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran

Source: Enzyme Research Published:2016

Abstract

Background and Aims. In the present study, we have investigated the activity of adenosine deaminase (ADA) as a diagnostic marker in type 2 (or II) diabetes mellitus (T2DM). Design and Methods. The deaminase activity of ADA1 and ADA2 was determined in serum from 33 patients with type 2 (or II) diabetes mellitus and 35 healthy controls. We also determined the proportion of glycated hemoglobin (HbA1c). Results. Our results showed significant differences between total serum ADA (tADA) and ADA2 activities in the diabetic groups with HbA1c < 8 (%) and HbA1c ≥ 8 (%) with respect to the values in healthy individuals (p<0.001). ADA2 activity in patients with high HbA1c was found to be much higher than that in patients with low HbA1c (p=0.0001). In addition, total ADA activity showed a significant correlation with HbA1c (r=0.6, p<0.0001). Conclusions. Total serum ADA activity, specially that due to ADA2, could be useful test for the diagnosis of type 2 (or II) diabetes mellitus. © 2016 Bagher Larijani et al.

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Style	Citing Format
MLA	Larijani B, et al.. "Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus." Enzyme Research, vol. 2016, no. , 2016, pp. -.
APA	Larijani B, Heshmat R, Ebrahimirad M, Khatami S, Valadbeigi S, Saghiri R (2016). Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus. Enzyme Research, 2016(), -.
Chicago	Larijani B, Heshmat R, Ebrahimirad M, Khatami S, Valadbeigi S, Saghiri R. "Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus." Enzyme Research 2016, no. (2016): -.
Harvard	Larijani B et al. (2016) 'Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus', Enzyme Research, 2016(), pp. -.
Vancouver	Larijani B, Heshmat R, Ebrahimirad M, Khatami S, Valadbeigi S, Saghiri R. Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus. Enzyme Research. 2016;2016():-.
BibTex	@article{ author = {Larijani B and Heshmat R and Ebrahimirad M and Khatami S and Valadbeigi S and Saghiri R}, title = {Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus}, journal = {Enzyme Research}, volume = {2016}, number = {}, pages = {-}, year = {2016} }
RIS	TY - JOUR AU - Larijani B AU - Heshmat R AU - Ebrahimirad M AU - Khatami S AU - Valadbeigi S AU - Saghiri R TI - Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type Ii Diabetes Mellitus JO - Enzyme Research VL - 2016 IS - SP - EP - PY - 2016 ER -

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