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Impact of Lifestyle Modification Counselling by the Tajik Method on Hormonal Profiles and Pregnancy Rates in Women With Poi: A Randomized Controlled Trial at Fatemieh Hospital, Hamadan, 2024 Publisher Pubmed



Hosseinpoor M ; Kazemi F ; Masoumi SZ ; Tajiki F ; Pakniyat Y ; Mollabashi M ; Chelopaz H ; Oliaei SMH
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Source: Reviews on Recent Clinical Trials Published:2025


Abstract

Introduction: Reduction in the quantity and quality of ova during the reproductive period of women is a physiological phenomenon. However, in some women, the deterioration of the ovaries occurs suddenly, and they experience infertility due to premature ovarian failure. This study aimed to explore the correlation between Primary ovarian insufficiency (POI) and the pregnancy rate of women in relation to the Tajik lifestyle modification diet. Methods: In this clinical randomized controlled trial study conducted in 2023, 72 infertile couples were randomly assigned to two groups, control and intervention. The intervention group received Tajik counseling sessions. In cases of normal distribution, the ANCOVA test was used to evaluate the difference between the two groups, and within-group comparisons were made using a paired t-test, while between-group comparisons were made using an independent t-test. A significance level of less than 0.05 was considered. Results: In comparison to the control group, women with POI exhibited notably lower levels of follicle-stimulating hormone, luteinizing hormone, and prolactin, along with higher anti-mullein levels. Within the intervention group, there were 17 successful pregnancies, two miscarriages, and 14 instances of improved menstrual status, resulting in a pregnancy rate of 52.7%. Discussion: After receiving lifestyle modification advice using the Tajik method, women with POI experienced improvements in their FSH, LH, AMH, and PRL hormone levels, leading to an increase in their pregnancy rate. Conclusion: According to the results of the present study, the use of the Tajik method is recommended to help treat POI. © 2025 Elsevier B.V., All rights reserved.
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