Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Circular Rna; a New Biomarker for Breast Cancer: A Systematic Review Publisher Pubmed



Jahani S1, 2 ; Nazeri E1 ; Majidzadeha K1 ; Jahani M3 ; Esmaeili R1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  2. 2. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Crop Protection, Laboratory of Agrozoology, Ghent University, Ghent, Belgium

Source: Journal of Cellular Physiology Published:2020


Abstract

Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell-type and stage-specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed. © 2020 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. A New World of Biomarkers and Therapeutics for Female Reproductive System and Breast Cancers: Circular Rnas, Frontiers in Cell and Developmental Biology (2020)
2. Circular Rnas and Gastrointestinal Cancers: Epigenetic Regulators With a Prognostic and Therapeutic Role, Critical Reviews in Oncology/Hematology (2020)
3. Circular Rnas in Alzheimer’S Disease: A New Perspective of Diagnostic and Therapeutic Targets, CNS and Neurological Disorders - Drug Targets (2023)
4. Circular Rnas in Tuberculosis: From Mechanism of Action to Potential Diagnostic Biomarker, Microbial Pathogenesis (2023)
5. Circ_0067934 As a Novel Therapeutic Target in Cancer: From Mechanistic to Clinical Perspectives, Pathology Research and Practice (2023)
6. Circrnas: A Novel Strategy in Diagnosis and Treatment of Thyroid Cancer, Current Molecular Medicine (2023)
7. Multiple Novel Functions of Circular Rnas in Diabetes Mellitus, Archives of Physiology and Biochemistry (2023)
8. The Potential Role of Circular Rnas in Regulating P53 in Different Types of Cancers, Pathology Research and Practice (2024)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Abbas Shakoori farahani (3)
Other Related Docs
9. Competing Endogenous Rna (Cerna) Cross Talk and Language in Cerna Regulatory Networks: A New Look at Hallmarks of Breast Cancer, Journal of Cellular Physiology (2019)
10. Circular Rnas (Circrnas) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets, Non-coding RNA Transcripts In Cancer Therapy: Pre-clinical And Clinical Implications (2023)
11. The Effective Function of Circular Rna in Colorectal Cancer, Cancer Cell International (2021)
12. Non-Coding Rnas and Exosomal Non-Coding Rnas in Traumatic Brain Injury: The Small Player With Big Actions, Molecular Neurobiology (2023)
13. Circular Rnas in Glioblastoma, Clinica Chimica Acta (2025)
14. The Importance of the Circrna/Wnt Axis in Gliomas: Biological Functions and Clinical Opportunities, Pathology Research and Practice (2024)
15. Constructing Mrna, Mirna, Circrna and Lncrna Regulatory Network by Analysis of Microarray Data in Breast Cancer, Gene Reports (2022)
16. Gynecologic Cancers and Non-Coding Rnas: Epigenetic Regulators With Emerging Roles, Critical Reviews in Oncology/Hematology (2021)
17. The Critical Role of Circular Rnas in Drug Resistance in Gastrointestinal Cancers, Medical Oncology (2023)
18. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
19. The Role of Long Non-Coding Rnas and Circular Rnas in Cervical Cancer: Modulating Mirna Function, Frontiers in Cell and Developmental Biology (2024)
20. Microrna-155 and Its Exosomal Form: Small Pieces in the Gastrointestinal Cancers Puzzle, Cell Biology and Toxicology (2024)
21. Melatonin Targeting Non-Coding Rnas in Cancer: Focus on Mechanisms and Potential Therapeutic Targets, European Journal of Pharmacology (2023)
22. Circular Rnas in Renal Cell Carcinoma: Functions in Tumorigenesis and Diagnostic and Prognostic Potentials, Pathology Research and Practice (2022)
23. Circular Rnas in Laryngeal Cancer, Clinica Chimica Acta (2025)
24. Exosomal Non-Coding Rnas: Emerging Therapeutic Targets in Atherosclerosis, Biochemical Pharmacology (2023)
25. The Role of Asxl1 Mutations and Asxl1 Circrnas in Cancer, Biomarkers (2024)
26. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)
27. Prospect of Exosomal Circular Rnas in Breast Cancer: Presents and Future, Molecular Biology Reports (2022)
28. Emerging Functions and Significance of Circcdyl in Human Disorders, Molecular Biology Reports (2024)
29. Circular Rnas: New Genetic Tools in Melanoma, Biomarkers in Medicine (2020)
30. The Function and Mechanism of Circrnas in 5-Fluorouracil Resistance in Tumors: Biological Mechanisms and Future Potential, Pathology Research and Practice (2024)
31. Non-Coding Rnas As Potential Therapeutic Targets for Receptor Tyrosine Kinase Signaling in Solid Tumors: Current Status and Future Directions, Cancer Cell International (2024)
32. Competing Endogenous Rnas (Cernas): Novel Network in Neurological Disorders, Current Medicinal Chemistry (2021)
33. Competing Endogenous Rnas Regulatory Crosstalk Networks: The Messages From the Rna World to Signaling Pathways Directing Cancer Stem Cell Development, Heliyon (2024)
34. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)
35. Integrative and In-Vitro Analysis Reveal Hsa_Circ_001787 Can Act As a Diagnostic Biomarker for Colorectal Cancer: Integrative and In-Vitro Analysis Reveal Hsa_Circ_001787, Saudi Journal of Biological Sciences (2021)
36. Analyzing the Role of Circsnx5 in an Animal Model of Multiple Sclerosis, Iranian Journal of Allergy, Asthma and Immunology (2025)
37. Exosomal Noncoding Rnas: Key Players in Glioblastoma Drug Resistance, Molecular and Cellular Biochemistry (2021)
38. The Effects of Exercise on Epigenetic Modifications: Focus on Dna Methylation, Histone Modifications and Non-Coding Rnas, Human Cell (2024)
39. Circrnas in Diagnosis, Prognosis, and Clinicopathological Features of Multiple Myeloma; a Systematic Review and Meta-Analysis, Cancer Cell International (2023)
40. Evaluation of Circ_0000977-Mediated Regulatory Network in Breast Cancer: A Potential Discriminative Biomarker for Triple-Negative Tumors, Biochemical Genetics (2023)
41. Critical Involvement of Circular Rnas in Virus-Associated Cancers, Genes and Diseases (2023)
42. Potential Roles of Hsa_Circ_000839 and Hsa_Circ_0005986 in Breast Cancer, Journal of Clinical Laboratory Analysis (2022)
43. Non-Coding Rnas and Exosomal Non-Coding Rnas in Pituitary Adenoma, Pathology Research and Practice (2023)
44. A Comprehensive Review of the Pten/Pi3k/Akt Axis in Multiple Myeloma: From Molecular Interactions to Potential Therapeutic Targets, Pathology Research and Practice (2024)
45. Circular Rna Hsa_Circ_0044234 As Distinct Molecular Signature of Triple Negative Breast Cancer: A Potential Regulator of Gata3, Cancer Cell International (2021)
46. Cytokine Storm in the Pathophysiology of Covid-19: Possible Functional Disturbances of Mirnas, International Immunopharmacology (2021)
47. Nlrp3 Inflammasome Pathway in Atherosclerosis: Focusing on the Therapeutic Potential of Non-Coding Rnas, Pathology Research and Practice (2023)
48. An Overview of Long Noncoding Rnas: Biology, Functions, Therapeutics, Analysis Methods, and Bioinformatics Tools, Cell Biochemistry and Function (2022)
49. Immune Checkpoints and Ncrnas: Pioneering Immunotherapy Approaches for Hematological Malignancies, Cancer Cell International (2024)
50. A Comprehensive Review on Mir-146A Molecular Mechanisms in a Wide Spectrum of Immune and Non-Immune Inflammatory Diseases, Immunology Letters (2020)