Role of Non-Coding Rnas in Neuroblastoma Publisher Pubmed



Anoushirvani AA¹ ; Jafarian Yazdi A² ; Amirabadi S³ ; Asouri SA⁴ ; Shafabakhsh R⁴ ; Sheida A^{5, 6} ; Hosseini Khabr MS^{5, 6} ; Jafari A^{7, 8} ; Tamehri Zadeh SS⁹ ; Hamblin MR¹⁰ ; Kalantari L⁵ ; Talaei Zavareh SA¹¹ ; Mirzaei H⁴ Show Affiliations
Source: Cancer Gene Therapy Published:2023

Abstract

Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.