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Resveratrol in Cancer Therapy: From Stimulation of Genomic Stability to Adjuvant Cancer Therapy: A Comprehensive Review Publisher Pubmed



Amini P1 ; Moazamiyanfar R2 ; Dakkali MS3 ; Khani A4 ; Jafarzadeh E5 ; Mouludi K6 ; Khodamoradi E6 ; Johari R7 ; Taeb S8, 9 ; Najafi M1, 6
Authors
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Authors Affiliations
  1. 1. Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  4. 4. Department of Radiation Sciences, Alley School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  5. 5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kerman-shah University of Medical Sciences, Kermanshah, Iran
  7. 7. Department of Technologic Radiologic, School of Allied of Medical Sciences, Ahvaz Jundishapur University, Ahvaz, Iran
  8. 8. Department of Radiology, School of Paramedical Sci-ences, Guilan University of Medical Sciences, Rasht, Iran
  9. 9. Medical Biotechnology Research Center, School of Para-medical Sciences, Guilan University of Medical Sciences, Rasht, Iran

Source: Current Topics in Medicinal Chemistry Published:2023


Abstract

Cancer therapy through anticancer drugs and radiotherapy is associated with several side effects as well as tumor resistance to therapy. The genotoxic effects of chemotherapy and radiotherapy may lead to genomic instability and increased risk of second cancers. Furthermore, some responses in the tumor may induce the exhaustion of antitumor immunity and increase the resistance of cancer cells to therapy. Administration of low-toxicity adjuvants to protect normal tissues and improve therapy efficacy is an intriguing strategy. Several studies have focused on natural-derived agents for improving the antitumor efficiency of radiotherapy, chemotherapy, and novel anticancer drugs such as immunotherapy and targeted cancer therapy. Resveratrol is a naturally occurring substance with intriguing antioxidant, cardioprotective, anti-diabetes, and antitumor properties. Resveratrol has been demonstrated to modulate tumor resistance and mitigate normal tissue toxicity following exposure to various drugs and ionizing radiation. Compelling data suggest that resveratrol may be an appealing adjuvant in combination with various anticancer modalities. Although the natural form of resveratrol has some limitations, such as low absorption in the intestine and low bioavailability, several experiments have demonstrated that using certain carriers, such as nanoparticles, can increase the therapeutic efficacy of resveratrol in preclinical studies. This review highlights various effects of resveratrol that may be useful for cancer therapy. Consequently, we describe how resveratrol can protect normal tissue from genomic instability. In addition, the various mechanisms by which resveratrol exerts its antitumor effects are addressed. Moreover, the outcomes of combination therapy with resveratrol and other anticancer agents are reviewed. © 2023 Bentham Science Publishers.
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