Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma

Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma Publisher Pubmed

Moghimi S^{1, 2} ; Nekoozadeh S² ; Motamedgorji N² ; Chen R³ ; Fard MA² ; Mohammadi M² ; Weinreb RN¹

Show Affiliations

1. Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, CA, United States
2. Tehran University of Medical Sciences, Tehran, Iran
3. Case Western Reserve University School of Medicine, Cleveland, OH, United States

Source: Investigative Ophthalmology and Visual Science Published:2018

Abstract

PURPOSE. To better understand the relationship of lamina cribrosa (LC) and choroid features to the severity of pseudoexfoliation glaucoma (PXG). METHODS. In this cross-sectional study, 137 eyes of 122 subjects (47 eyes with moderate/ advanced PXG [mean deviation (MD), 15.0 ± 7.7 dB], 34 eyes with mild PXG [MD, 2.7 ± 1.5 dB], 32 aged-matched pseudoexfoliation syndrome [PXS] eyes, and 24 aged-matched control eyes) were investigated. Optic discs, LC thickness, and anterior LC depth (ALD; midsuperior, center, and midinferior) as well as peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust for age, sex, and axial length. RESULTS. A progressive decrease in LC thickness was found when comparing controls (271.9 ± 61.3 μm), PXS (212.6 ± 51.5 μm), mild PXG (180.8 ± 24.6 μm), and moderate/advance PXG (138.9 ± 37.5 μm) (P < 0.001). ALD was greater (P < 0.001) in moderate/advance glaucoma (306.7 ± 105.3 μm) and mild PXG (209.5 ± 79.7 μm) compared with PXS (155 ± 86.7 μm) and healthy controls (149.2 ± 103 μm). Although eyes with moderate/advance PXG had the thinnest choroid (117.2 ± 36.6 μm), choroidal thickness was comparable in mild PXG, PXS, and controls (150.0 ± 46.1, 159.7 ± 65.5, and 157.5 ± 51.1 μm, respectively; P = 0.002). Worse MD was the only factor associated with thinner LC (β = 2.344, P < 0.001) and choroid (β = 1.717, P = 0.009 μm) in PXG eyes. Higher IOP (β = 4.305, P = 0.013) and worse MD (β = 6.390, P < 0.001) were associated with deeper ALD in PXG. CONCLUSIONS. In pseudoexfoliation, LC thinning is an early sign, and there is progressive thinning with advancing glaucoma. Choroidal thinning is observable only with moderate/ advanced glaucoma. In PXG eyes, LC thickness, depth, and peripapillary choroidal thickness are associated with glaucoma severity. © 2018 The Authors.

Related Docs

View other Related Docs

1. Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography, Investigative Ophthalmology and Visual Science (2016)

2. Comparison of Macular Choroidal Thickness in Patients With Pseudoexfoliation Syndrome to Normal Control Subjects With Enhanced Depth Sd-Oct Imaging, Journal of Current Ophthalmology (2017)

3. Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma, Investigative Ophthalmology and Visual Science (2016)

4. Association Between Lamina Cribrosa Defects and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma, JAMA Ophthalmology (2019)

5. Peripapillary Choroidal Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy, Investigative Ophthalmology and Visual Science (2015)

6. Factors Associated With Lamina Cribrosa Displacement After Trabeculectomy Measured by Optical Coherence Tomography in Advanced Primary Open-Angle Glaucoma, Graefe's Archive for Clinical and Experimental Ophthalmology (2018)

7. Automated Evaluation of Parapapillary Choroidal Microvasculature in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma, American Journal of Ophthalmology (2021)

8. Parapapillary Choroidal Microvascular Density in Acute Primary Angle-Closure and Primary Open-Angle Glaucoma: An Optical Coherence Tomography Angiography Study, British Journal of Ophthalmology (2023)

Experts (# of related papers)

View all Related Experts

Masoud Aghsaei Fard (8)

Mehdi Yaseri (3)

Style	Citing Format
MLA	Moghimi S, et al.. "Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma." Investigative Ophthalmology and Visual Science, vol. 59, no. 13, 2018, pp. 5355-5365.
APA	Moghimi S, Nekoozadeh S, Motamedgorji N, Chen R, Fard MA, Mohammadi M, Weinreb RN (2018). Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma. Investigative Ophthalmology and Visual Science, 59(13), 5355-5365.
Chicago	Moghimi S, Nekoozadeh S, Motamedgorji N, Chen R, Fard MA, Mohammadi M, Weinreb RN. "Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma." Investigative Ophthalmology and Visual Science 59, no. 13 (2018): 5355-5365.
Harvard	Moghimi S et al. (2018) 'Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma', Investigative Ophthalmology and Visual Science, 59(13), pp. 5355-5365.
Vancouver	Moghimi S, Nekoozadeh S, Motamedgorji N, Chen R, Fard MA, Mohammadi M, et al.. Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma. Investigative Ophthalmology and Visual Science. 2018;59(13):5355-5365.
BibTex	@article{ author = {Moghimi S and Nekoozadeh S and Motamedgorji N and Chen R and Fard MA and Mohammadi M and Weinreb RN}, title = {Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma}, journal = {Investigative Ophthalmology and Visual Science}, volume = {59}, number = {13}, pages = {5355-5365}, year = {2018} }
RIS	TY - JOUR AU - Moghimi S AU - Nekoozadeh S AU - Motamedgorji N AU - Chen R AU - Fard MA AU - Mohammadi M AU - Weinreb RN TI - Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma JO - Investigative Ophthalmology and Visual Science VL - 59 IS - 13 SP - 5355 EP - 5365 PY - 2018 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract