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Phoenix Dactylifera L. Pollen Versus Pentoxifylline on Improvement of Sperm Parameters in Idiopathic Male Infertility: A Randomized Clinical Trial Publisher Pubmed



Mirzaei M1, 2 ; Asbagh FA3 ; Safavi M4 ; Yekaninejad MS5 ; Rahimi R6 ; Pourmand G4 ; Karimi M2 ; Farshbafkhalili A7 ; Sarrafi S8
Authors
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Authors Affiliations
  1. 1. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Obstetrics and Gynecology, IVF Unit, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Traditional Pharmacy, School of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Physical Medicine and Rehabilitation Research Center, Aging Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Instructor, Midwifery Department, Bonab Branch, Islamic Azad University, Bonab, Iran

Source: Journal of Ethnopharmacology Published:2024


Abstract

Ethnopharmacological relevance: Phoenix dactylifera L. pollen is the male reproductive dust of palm flowers known as a natural product that is considered a strong stimulant of sexual potency and fertility in Iranian traditional medicine (ITM). In this regard, no evidence-based medications are empirically prescribed to treat IMI. However, applying traditional medicine for the treatment of male infertility has attracted more attention in recent years. Aim of the study: Phoenix dactylifera L. pollen was compared with pentoxifylline (PTX) to evaluate its efficacy on sperm parameters. Materials and methods: During this parallel randomized controlled trial, 80 adult men with asthenozoospermia, oligozoospermia, or teratozoospermia (age 20–35 years) were enrolled. In two separate groups of participants with a 1:1 ratio, participants received either 6 g of Phoenix dactylifera L. pollen powder daily or 400 mg of PTX tablets daily for 90 days. We measured the sperm parameters as well as the serum sex hormones in the sample. ANCOVA and t-tests were used to compare groups. Results: There was no significant difference between the study groups in terms of baseline characteristics or demographic characteristics. According to the results, participants who took Phoenix dactylifera L. pollen powder had significantly improved sperm concentration (p = 0.016), morphology (p = 0.029), sperm counts (p = 0.012), progressive motility (p = 0.016), total motility (p = 0.018), and reduced immotile sperms (p = 0.014) compared to those who took PTX. Conclusions: In light of these results, Phoenix dactylifera L. pollen is recommended as a treatment factor for ameliorating IMI by enhancing sperm functional capacity and semen parameters. © 2024 Elsevier B.V.
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