Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51)

Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51) Publisher Pubmed

Azimzadeh K¹ ; Nasrollahi Nargesabad R² ; Vousooghi N^{3, 4, 5}

Show Affiliations

1. Young Researcher and Elite Club, Urmia Branch, Islamic Azad University, Urmia, Iran
2. International Associate Member of Microbiology Society, London, United Kingdom
3. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Genetics Laboratory, Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
5. Research Center for Cognitive and Behavioral Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Microbial Pathogenesis Published:2017

Abstract

Brucellosis is known as one of important zoonosis. Studying the histological and biochemical effects of the disease could help to increase our knowledge about it. The aim of the present study was to evaluate changes of plasma parameters after intraperitoneal injection of two species of Brucella (Brucella melitensis and Brucella abortus) and two vaccines (Rev-1, RB-51) in the rat. Forty male rats were divided into five groups (n = 8 in each group). Two groups received suspensions of Brucella abortus and Brucella melitensis and two other groups were injected intraperitoneally with two mentioned vaccines and the last group received only distilled water. The results showed a significant increase in sphingosine 1-phosphate, Malondialdehyde, hepcidin, homocysteine, cardiac troponin I and copper levels and a considerable decrease in the levels of iron and zinc (P ≤ 0.01) in infected groups compared to the control animals. In vaccinated groups, hepcidin was increased but other parameters were not changed in comparison to the control group. It can be concluded that increase of homocysteine and cardiac troponin I in brucellosis could be a warning for cardiac adverse effects. Besides, increase of sphingosine 1-phosphate probably indicates its stimulant and modulatory effects in anti- Brucellosis biochemical pathways of the host. © 2017 Elsevier Ltd

Related Docs

1. Dual Role of Hepcidin in Response to Pathogens, Microbial Pathogenesis (2025)

Experts (# of related papers)

Nima Rezaei (1)

Style	Citing Format
MLA	Azimzadeh K, Nasrollahi Nargesabad R, Vousooghi N. "Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51)." Microbial Pathogenesis, vol. 109, no. , 2017, pp. 67-70.
APA	Azimzadeh K, Nasrollahi Nargesabad R, Vousooghi N (2017). Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51). Microbial Pathogenesis, 109(), 67-70.
Chicago	Azimzadeh K, Nasrollahi Nargesabad R, Vousooghi N. "Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51)." Microbial Pathogenesis 109, no. (2017): 67-70.
Harvard	Azimzadeh K, Nasrollahi Nargesabad R, Vousooghi N (2017) 'Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51)', Microbial Pathogenesis, 109(), pp. 67-70.
Vancouver	Azimzadeh K, Nasrollahi Nargesabad R, Vousooghi N. Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51). Microbial Pathogenesis. 2017;109():67-70.
BibTex	@article{ author = {Azimzadeh K and Nasrollahi Nargesabad R and Vousooghi N}, title = {Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51)}, journal = {Microbial Pathogenesis}, volume = {109}, number = {}, pages = {67-70}, year = {2017} }
RIS	TY - JOUR AU - Azimzadeh K AU - Nasrollahi Nargesabad R AU - Vousooghi N TI - Evaluation of Plasma Sphingosine 1-Phosphate, Hepcidin and Cardiovascular Damage Biomarkers (Cardiac Troponin I and Homocysteine) in Rats Infected With Brucellosis and Vaccinated (Rev-1, Rb-51) JO - Microbial Pathogenesis VL - 109 IS - SP - 67 EP - 70 PY - 2017 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract