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Investigation of Polysaccharide Extracts From Iranian and French Strains of Agaricus Subrufescens Against Enzymes Involved in Alzheimer’S Disease; [Investigacion De Extractos De Polisacaridos De Cepas Iranies Y Francesas De Agaricus Subrufescens Contra Enzimas Relevantes Para La Enfermedad De Alzheimer] Publisher



Rahmaninezhad S1 ; Dianat S1 ; Mahdizadeh V2 ; Fooladi Z3 ; Hariri R4 ; Najafi Z5 ; Firuzi O6 ; Vahedimazdabadi Y7 ; Farjadmand F7 ; Akbarzadeh T4, 7 ; Saeedi M1, 7 ; Ardekani MS3, 7
Authors
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Authors Affiliations
  1. 1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Published:2019


Abstract

In this work, the inhibitory activity of a wide range of polysaccharide extracts from two Iranian and French strains of Agaricus subrufescens were evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among them, two extracts S9 and S′7 obtained from Iranian and French strains under different extraction conditions showed selective AChE inhibitory activity with IC50 values of 154.63 and 145.43 μg/mL, respectively. It should be noted that all extracts from both strains demonstrated no BChE inhibitory activity. S9 and S′7 were also tested for their effect on amyloid beta (Aβ) aggregation, antioxidant activity, and neuroprotectivity. Their activity against Aβ aggregation was comparable to that of donepezil as the reference drug but they induced moderate antioxidant activity by DPPH radical scavenging activity and negligible neuroprotectivity against Aβ-induced damage. © 2019, Universidad de Santiago de Chile. All rights reserved.
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