Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Investigation of Polysaccharide Extracts From Iranian and French Strains of Agaricus Subrufescens Against Enzymes Involved in Alzheimer’S Disease; [Investigacion De Extractos De Polisacaridos De Cepas Iranies Y Francesas De Agaricus Subrufescens Contra Enzimas Relevantes Para La Enfermedad De Alzheimer]
Tahmineh Akbarzadeh
Tahmineh Akbarzadeh

Professor of Pharmaceutical Chemistry

Department Medicinal Chemistry

School of Pharmacy

Tehran University of Medical Sciences

Related Documents
1. Investigation of Polysaccharide Extracts From Iranian and French Strains of Agaricus Subrufescens Against Enzymes Involved in Alzheimer’S Disease; [Investigacion De Extractos De Polisacaridos De Cepas Iranies Y Francesas De Agaricus Subrufescens Contra Enzimas Relevantes Para La Enfermedad De Alzheimer], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2019)
2. Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2021)
3. Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds, Natural Product Research (2020)
4. Cinnamomum Verum J. Presl. Bark Essential Oil: In Vitro Investigation of Anti-Cholinesterase, Anti-Bace1, and Neuroprotective Activity, BMC Complementary Medicine and Therapies (2022)
5. Novel Tetrahydrocarbazole Benzyl Pyridine Hybrids As Potent and Selective Butryl Cholinesterase Inhibitors With Neuroprotective and Β-Secretase Inhibition Activities, European Journal of Medicinal Chemistry (2018)
6. Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs As Potent Anti-Alzheimer's Agents, Chemistry and Biodiversity (2019)
7. Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives, Chemistry and Biodiversity (2019)
8. Design, Synthesis and Anti-Alzheimer's Activity of Novel 1,2,3-Triazole-Chromenone Carboxamide Derivatives, Bioorganic Chemistry (2019)
9. Design and Synthesis of Multi-Target Directed 1,2,3-Triazole-Dimethylaminoacryloyl-Chromenone Derivatives With Potential Use in Alzheimer's Disease, BMC Chemistry (2020)
10. Novel Tacrine-Coumarin Hybrids Linked to 1,2,3-Triazole As Anti-Alzheimer's Compounds: In Vitro and in Vivo Biological Evaluation and Docking Study, Bioorganic Chemistry (2019)
11. Novel Tacrine-Based Acetylcholinesterase Inhibitors As Potential Agents for the Treatment of Alzheimer’S Disease: Quinolotacrine Hybrids, Molecular Diversity (2022)
12. Synthesis and Evaluation of Novel Arylisoxazoles Linked to Tacrine Moiety: In Vitro and in Vivo Biological Activities Against Alzheimer’S Disease, Molecular Diversity (2022)
All Documents
1. Design and Synthesis of New 1,2,3-Triazole-Methoxyphenyl-1,3,4-Oxadiazole Derivatives: Selective Butyrylcholinesterase Inhibitors Against Alzheimer’S Disease, BMC Chemistry (2025)
2. Design and Synthesis of New Substituted Benzyl-1,2,3-Triazole-Methoxybenzylidene Coupled to Arylacetohydrazides Against Alzheimer's Disease, Journal of Molecular Structure (2025)
3. Design, Synthesis, and Investigation of Novel 5-Arylpyrazole-Glucose Hybrids As Α-Glucosidase Inhibitors, Scientific Reports (2025)
4. Design, Synthesis, Anticancer Properties, and Molecular Dynamics of New Quinazolinonethioacetohydrazide-1,2,3-Triazoles, Chemistry and Biodiversity (2025)
5. Design, Synthesis, Anticonvulsant Evaluation, and Molecular Docking Studies of New Gabaa Agonist Derivatives, Iranian Journal of Pharmaceutical Research (2025)
6. Neuroprotective, and Memory Enhancement Effects of Salvia Aristata and Its Phenolic Constituents: An in Vitro, and in Vivo Study, BMC Complementary Medicine and Therapies (2025)
7. Synthesis and Evaluation of Quinolinvinyl-Phenoxy-1,2,3-Triazole-Acetamide Hybrids Against Breast Cancer, Scientific Reports (2025)
8. In Vitro Anti-Hsv1 Activity of Aqueous Extract of Areca Catechu L., Iranian Journal of Microbiology (2024)
9. Oleo-Gum-Resin of Ferula Persica: Phytochemical Analysis and Enzyme Inhibitory Activity Related to Alzheimer’S Disease, Research Journal of Pharmacognosy (2024)
10. Synthesis of New Glucose-Containing 5-Arylisoxazoles and Their Enzyme Inhibitory Activity, Letters in Organic Chemistry (2024)
11. Synthesis of Novel Hybrids of 1,2,3-Triazoles-Hydrazone: Targeting Cholinesterases and Alzheimer's Related Genes, Future Medicinal Chemistry (2024)
12. Cedrus Deodara: In Vivo Investigation of Burn Wound Healing Properties, Evidence-based Complementary and Alternative Medicine (2023)
13. Design, Synthesis, in Vitro, and in Silico Studies of Novel Benzylidene 6-Methoxy-1-Tetralone Linked to Benzyloxy and Benzyl -1,2,3- Triazole Rings As Potential Tyrosinase Inhibitors, Journal of Molecular Structure (2023)
14. Fused 1,4-Dihydropyridines and Their Corresponding Pyridines: Synthesis, Molecular Modeling and Cholinesterase Inhibition, ChemistrySelect (2023)
15. Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman, Research Journal of Pharmacognosy (2023)
16. Novel Indolotacrine Hybrids As Acetylcholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies, Journal of the Iranian Chemical Society (2023)
17. Novel N′-Substituted Benzylidene Benzohydrazides Linked to 1,2,3-Triazoles: Potent Α-Glucosidase Inhibitors, Scientific Reports (2023)
18. Phytochemical Investigation and Biological Activity of Doronicum Pardalianches L. Roots Against Alzheimer’S Disease, Natural Product Research (2023)
19. Quinazolinone-1,2,3-Triazole-Acetamide Conjugates As Potent Α-Glucosidase Inhibitors: Synthesis, Enzyme Inhibition, Kinetic Analysis, and Molecular Docking Study, RSC Medicinal Chemistry (2023)
20. 6-Methoxy-1-Tetralone Derivatives Bearing an N-Arylpyridinium Moiety As Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Molecular Docking Study, ChemistrySelect (2022)
21. Cinnamomum Verum J. Presl. Bark Essential Oil: In Vitro Investigation of Anti-Cholinesterase, Anti-Bace1, and Neuroprotective Activity, BMC Complementary Medicine and Therapies (2022)
22. Correction: Cinnamomum Verum J. Presl. Bark Essential Oil: In Vitro Investigation of Anti-Cholinesterase, Anti-Bace1, and Neuroprotective Activity (Bmc Complementary Medicine and Therapies, (2022), 22, 1, (303), 10.1186/S12906-022-03767-Y), BMC Complementary Medicine and Therapies (2022)
23. Cyanoacetohydrazide Linked to 1,2,3-Triazole Derivatives: A New Class of Α-Glucosidase Inhibitors, Scientific Reports (2022)
24. In Vivo Evaluation of Wound Healing Properties of Platanus Orientalis L, Pharmaceutical Sciences (2022)
25. Novel 3-Aminobenzofuran Derivatives As Multifunctional Agents for the Treatment of Alzheimer’S Disease, Frontiers in Chemistry (2022)
26. Novel Tacrine-Based Acetylcholinesterase Inhibitors As Potential Agents for the Treatment of Alzheimer’S Disease: Quinolotacrine Hybrids, Molecular Diversity (2022)
27. Phytochemical Analysis and Anticholinesterase Activity of Aril of Myristica Fragrans Houtt, BMC Chemistry (2022)
28. Synthesis and Evaluation of Novel Arylisoxazoles Linked to Tacrine Moiety: In Vitro and in Vivo Biological Activities Against Alzheimer’S Disease, Molecular Diversity (2022)
29. Ugi Adducts: Design and Synthesis of Natural-Based Α-Glucosidase Inhibitors, Letters in Organic Chemistry (2022)
30. Ultrasound-Assisted Synthesis of Kojic Acid-1,2,3-Triazole Based Dihydropyrano[3,2-B]Pyran Derivatives Using Fe3o4@Cqd@Cui As a Novel Nanomagnetic Catalyst, Scientific Reports (2022)
31. Anti-Helicobacter Pylori Compounds From Oliveria Decumbens Vent. Through Urease Inhibitory In-Vitro and In-Silico Studies, Iranian Journal of Pharmaceutical Research (2021)
32. Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-Thiadiazole Hybrids As Α-Glucosidase Inhibitors, Letters in Drug Design and Discovery (2021)
33. Design, Synthesis and Biological Assessment of New 1-Benzyl-4-((4-Oxoquinazolin-3(4H)-Yl)Methyl) Pyridin-1-Ium Derivatives (Bops) As Potential Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase, Heliyon (2021)
34. Design, Synthesis, and Molecular Docking of Some Novel Tacrine Based Cyclopentapyranopyridine- and Tetrahydropyranoquinoline-Kojic Acid Derivatives As Anti-Acetylcholinesterase Agents, Chemistry and Biodiversity (2021)
35. Design, Synthesis, Andin Vitroandin Vivoevaluation of Novel Fluconazole-Based Compounds With Promising Antifungal Activities, ACS Omega (2021)
36. Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2021)
37. Naturally Occurring and Synthetic Peptides: Efficient Tyrosinase Inhibitors, Journal of Peptide Science (2021)
38. Novel 1,2,4-Oxadiazole Derivatives As Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, and Biological Evaluation, EXCLI Journal (2021)
39. Novel N-Benzylpiperidine Derivatives of 5-Arylisoxazole-3-Carboxamides As Anti-Alzheimer's Agents, Archiv der Pharmazie (2021)
40. Phytochemical Analysis and Evaluation of Biological Activity of Lawsonia Inermis Seeds Related to Alzheimer's Disease, Evidence-based Complementary and Alternative Medicine (2021)
41. Phytochemical Constituents and Biological Activities of Salvia Macrosiphon Boiss., BMC Chemistry (2021)
42. Synthesis and Bio-Evaluation of New Multifunctional Methylindolinone-1,2,3-Triazole Hybrids As Anti-Alzheimer's Agents, Journal of Molecular Structure (2021)
43. Synthesis of 4-Alkylaminoimidazo[1,2-A]Pyridines Linked to Carbamate Moiety As Potent Α-Glucosidase Inhibitors, Molecular Diversity (2021)
44. Synthesis, in Vitro Evaluation, and Molecular Docking Studies of Novel Hydrazineylideneindolinone Linked to Phenoxymethyl-1,2,3-Triazole Derivatives As Potential Α-Glucosidase Inhibitors, Bioorganic Chemistry (2021)
45. Anti-Cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus Armeniaca L.), Iranian Journal of Pharmaceutical Research (2020)
46. Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, in Vivo Biological Evaluation, and Docking Study, Letters in Drug Design and Discovery (2020)
47. Design and Synthesis of Multi-Target Directed 1,2,3-Triazole-Dimethylaminoacryloyl-Chromenone Derivatives With Potential Use in Alzheimer's Disease, BMC Chemistry (2020)
48. Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated With Alzheimer's Disease, Chemistry and Biodiversity (2020)
49. Design, Synthesis, and Evaluation of Novel Cinnamic Acid-Tryptamine Hybrid for Inhibition of Acetylcholinesterase and Butyrylcholinesterase, DARU# Journal of Pharmaceutical Sciences (2020)
50. Design, Synthesis, in Vivo and in Vitro Studies of 1,2,3,4-Tetrahydro-9H-Carbazole Derivatives, Highly Selective and Potent Butyrylcholinesterase Inhibitors, Molecular Diversity (2020)
51. Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds, Natural Product Research (2020)
52. Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide, Polycyclic Aromatic Compounds (2020)
53. Thieno[2,3-B]Pyridine Amines: Synthesis and Evaluation of Tacrine Analogs Against Biological Activities Related to Alzheimer's Disease, Archiv der Pharmazie (2020)
54. Design and Synthesis of Novel Quinazolinone-1,2,3-Triazole Hybrids As New Anti-Diabetic Agents: In Vitro Α-Glucosidase Inhibition, Kinetic, and Docking Study, Bioorganic Chemistry (2019)
55. Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives, Chemistry and Biodiversity (2019)
56. Design, Synthesis and Anti-Alzheimer's Activity of Novel 1,2,3-Triazole-Chromenone Carboxamide Derivatives, Bioorganic Chemistry (2019)
57. Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-Triazole-1,2,4-Oxadiazole Hybrids As Potent Anti-Breast Cancer Agents, Letters in Drug Design and Discovery (2019)
58. Design, Synthesis, Biological Evaluation, and Molecular Dynamics of Novel Cholinesterase Inhibitors As Anti-Alzheimer's Agents, Archiv der Pharmazie (2019)
59. Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors, Bioorganic and Medicinal Chemistry (2019)
60. Design, Synthesis, in Vivo, and in Silico Evaluation of New Coumarin-1,2,4-Oxadiazole Hybrids As Anticonvulsant Agents, Bioorganic Chemistry (2019)
61. Facile Access to New Pyrido[2,3-D]Pyrimidine Derivatives, Molecular Diversity (2019)
62. Green Decarboxylative Aminoalkylation of Coumarin-3-Carboxylic Acids, ChemistrySelect (2019)
63. Investigation of Polysaccharide Extracts From Iranian and French Strains of Agaricus Subrufescens Against Enzymes Involved in Alzheimer’S Disease; [Investigacion De Extractos De Polisacaridos De Cepas Iranies Y Francesas De Agaricus Subrufescens Contra Enzimas Relevantes Para La Enfermedad De Alzheimer], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2019)
64. Novel N-Benzylpyridinium Moiety Linked to Arylisoxazole Derivatives As Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Evaluation, and Docking Study, Bioorganic Chemistry (2019)
65. Novel Tacrine-Coumarin Hybrids Linked to 1,2,3-Triazole As Anti-Alzheimer's Compounds: In Vitro and in Vivo Biological Evaluation and Docking Study, Bioorganic Chemistry (2019)
66. Oliveria Decumbens, a Bioactive Essential Oil: Chemical Composition and Biological Activities, Iranian Journal of Pharmaceutical Research (2019)
67. Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs As Potent Anti-Alzheimer's Agents, Chemistry and Biodiversity (2019)
68. Chemodiversity of Nepeta Menthoides Boiss. & Bohse. Essential Oil From Iran and Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Properties of 1,8-Cineole Chemotype, Natural Product Research (2018)
69. Design and Synthesis of Novel Coumarin-Pyridinium Hybrids: In Vitro Cholinesterase Inhibitory Activity, Bioorganic Chemistry (2018)
70. Design, Synthesis, and Biological Evaluation of Selective and Potent Carbazole-Based Butyrylcholinesterase Inhibitors, Bioorganic and Medicinal Chemistry (2018)
71. Novel Tetrahydrocarbazole Benzyl Pyridine Hybrids As Potent and Selective Butryl Cholinesterase Inhibitors With Neuroprotective and Β-Secretase Inhibition Activities, European Journal of Medicinal Chemistry (2018)
72. Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones, New Journal of Chemistry (2018)
73. Synthesis of New Benzimidazole-1,2,3-Triazole Hybrids As Tyrosinase Inhibitors, Chemistry and Biodiversity (2018)
74. 1,2,3-Triazole-Isoxazole Based Acetylcholinesterase Inhibitors: Synthesis, Biological Evaluation and Docking Study, Letters in Drug Design and Discovery (2017)
75. A Green and Efficient Synthesis of 2-Thioxoquinazolinone Derivatives in Water Using Potassium Thiocyanate, Journal of Sulfur Chemistry (2017)
76. In Vitro Cholinesterase Inhibitory Activity of Some Plants Used in Iranian Traditional Medicine, Natural Product Research (2017)
77. Novel Indole-Isoxazole Hybrids: Synthesis and in Vitro Anti-Cholinesterase Activity, Letters in Drug Design and Discovery (2017)
78. Novel Tacrine-1,2,3-Triazole Hybrids: In Vitro, in Vivo Biological Evaluation and Docking Study of Cholinesterase Inhibitors, European Journal of Medicinal Chemistry (2017)
79. Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents, Chemical Biology and Drug Design (2017)
80. Synthesis of Novel Chromenones Linked to 1,2,3-Triazole Ring System: Investigation of Biological Activities Against Alzheimer's Disease, Bioorganic Chemistry (2017)
81. Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors, Turkish Journal of Chemistry (2017)
82. Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors, Journal of Heterocyclic Chemistry (2017)
83. Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors, Letters in Organic Chemistry (2017)
84. An Evidence-Based Review on Medicinal Plants Used As Insecticide and Insect Repellent in Traditional Iranian Medicine, Iranian Red Crescent Medical Journal (2016)
85. Design and Synthesis of Novel Anti-Alzheimer's Agents: Acridine-Chromenone and Quinoline-Chromenone Hybrids, Bioorganic Chemistry (2016)
86. Design, Synthesis, Pharmacological Evaluation, and Docking Study of New Acridone-Based 1,2,4-Oxadiazoles As Potential Anticonvulsant Agents, European Journal of Medicinal Chemistry (2016)
87. In Vitro Antimicrobial and Acetylcholinesterase Inhibitory Activities of Coumarins From Ferulago Carduchorum, Medicinal Chemistry Research (2016)
88. Medicinal Plants Used in Iranian Traditional Medicine (Itm) As Contraceptive Agents, Current Pharmaceutical Biotechnology (2016)
89. Novel Tacrine-Based Pyrano[3’,4’:5,6]Pyrano[2,3-B]Quinolinones: Synthesis and Cholinesterase Inhibitory Activity, Archiv der Pharmazie (2016)
90. Phytochemical Analysis, Antimicrobial, Antioxidant Activities and Total Phenols of Ferulago Carduchorum in Two Vegetative Stages (Flower and Fruit), Pakistan Journal of Pharmaceutical Sciences (2016)
91. Synthesis and Cytotoxic Evaluation of Novel 1,2,3-Triazole-4-Linked (2E,6E)-2-Benzylidene-6-(4-Nitrobenzylidene)Cyclohexanones, Helvetica Chimica Acta (2016)
92. Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One, Monatshefte fur Chemie (2016)
93. Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-Oxadiazole-1,2,3-Triazole Hybrids, Chemical Biology and Drug Design (2015)
94. Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Apoptosis-Induction Study of New 9(10H-Acridinone-1,2,3-Triazoles, Molecular Diversity (2015)
95. Facile, Novel and Efficient Synthesis of New Pyrazolo[3,4-B]Pyridine Products From Condensation of Pyrazole-5-Amine Derivatives and Activated Carbonyl Groups, RSC Advances (2015)
96. Liver Tonics: Review of Plants Used in Iranian Traditional Medicine, Asian Pacific Journal of Tropical Biomedicine (2015)
97. Potent Acetylcholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Docking Study of Acridone Linked to 1,2,3-Triazole Derivatives, European Journal of Medicinal Chemistry (2015)
98. Simple and Efficient Syntheses of Novel Benzo[4,5]Imidazo[1,2-A]Pyridine Derivatives, Tetrahedron Letters (2015)
99. Synthesis and Cytotoxic Activity of Novel Poly-Substituted Imidazo[2,1-C][1,2,4]Triazin-6-Amines, Molecular Diversity (2015)
100. Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors, Journal of Sciences# Islamic Republic of Iran (2015)
101. Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors, Monatshefte fur Chemie (2015)
102. Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives, Journal of Heterocyclic Chemistry (2015)
103. Synthesis of New Benzo[F]Imidazo[1,2-D][1,4]Oxazepines: Agno3-Mediated Intramolecular Hydroamination, Tetrahedron Letters (2015)
104. Synthesis of Novel 1,2,3-Triazole-Dihydro[3,2-C[Chromenones As Acetylcholinesterase Inhibitors, Synthetic Communications (2015)