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Antibody-Mediated Rejection of Kidney Allografts Following Covid-19: A Report of Two Cases Publisher Pubmed



Fazeli SA1, 2, 3 ; Takyar M4 ; Parvin M5 ; Haririan A6 ; Alirezaei A1
Authors
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Authors Affiliations
  1. 1. Clinical Research and Development Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Anatomy, Faculty of Medicine, Gorgan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Source: Iranian Journal of Kidney Diseases Published:2022


Abstract

Increased risk of graft rejection could be the consequence of COVID-19 in kidney transplant recipients (KTRs). We report two cases of kidney transplant (KT) with stable graft function who experienced antibody-mediated rejection (ABMR) following recovery from COVID-19. It seems that reduced immunosuppression during the acute illness, is the main explanation for post-COVID-19 ABMR. However, the inflammatory state associated with COVID-19, as well as direct cytopathic effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can predispose the kidney allograft to rejection. There is no definite guideline for the modification of immunosuppressives during COVID-19 in kidney transplant recipients. However, re-institution of full-dose immunosuppressives soon after recovery from COVID-19 and frequent outpatient follow-up visits are recommended. © 2022, Iranian Society of Nephrology. All rights reserved.
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