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Antibiofilm Activity of Natural Zeolite Supported Nanozno: Inhibition of Esp Gene Expression of Enterococcus Faecalis Publisher Pubmed



Partoazar A1 ; Talaei N2, 3 ; Bahador A3 ; Pourhajibagher M4 ; Dehpour S1 ; Sadati M5 ; Bakhtiarian A6
Authors
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Authors Affiliations
  1. 1. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Oral Microbiology Laboratory, Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Science and Research Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2019


Abstract

Aim: To evaluate the antibiofilm effect and esp gene downregulation of Enterococcus faecalis through nanozinc oxide fabricated on natural zeolite (NanoZnO/Ze). Materials & methods:Zeolite and NanoZnO/Ze materials were characterized by X-ray diffraction, X-ray fluorescence and field emission scanning electron microscopy coupled with energy dispersive X-ray. Atomic absorption spectroscopy was used to evaluate zinc release. E. faecalis biofilm formation and its esp gene expression were assessed under nanocomposite treatment. Results: Spherical-shaped ZnO nanoparticles with an average size of 30 nm were dispersed on the zeolites surface. The leakage of cationic zinc from NanoZnO/Ze displayed a long lasting and considerable release content (p < 0.0001) compared with ZnO/Ze. NanoZnO/Ze effectively inhibited (p < 0.0001) biofilm formation and affected esp gene downregulation of E. faecalis. Conclusion: Our results show that NanoZnO/Zeolite can potentiate against biofilm infections due to E. faecalis and possibly other pathogens. © 2019 Future Medicine Ltd.
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