Meta-Analysis of Gene Expression Profiles in Acute Promyelocytic Leukemia Reveals Involved Pathways



Jalili M¹ ; Salehzadehyazdi A^{1, 2} ; Mohammadi S¹ ; Yaghmaie M¹ ; Ghavamzadeh A¹ ; Alimoghaddam K¹ Show Affiliations
Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2017

Abstract

Background: Acute promyelocytic leukemia (APL) is a unique subtype of acute leukemia. APL is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in APL patient management. One issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood. Materials and Methods: In this study, we performed a meta-analysis of gene expression profiles derived from microarray experiments and explored the background of disease by functional and pathway analysis. Results: Our analysis revealed a gene signature with 406 genes that are up or down-regulated in APL. The pathway analysis determined that MAPK pathway and its involved elements such as JUN gene and AP-1 play important roles in APL pathogenesis along with insulin-like growth factor-binding protein-7. Conclusions: The results of this meta-analysis could be useful for developing more effective therapy strategies and new targets for diagnosis and drugs. © 2017, Tehran University of Medical Sciences (TUMS). All rights reserved.