Efficacy of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on Patients With History of Implantation Failure: A Randomized Control Trial Publisher



Eftekhar M¹ ; Miraj S^{1, 2} ; Mojtahedi MF³ ; Neghab N¹ Show Affiliations
Source: International Journal of Reproductive BioMedicine Published:2016

Abstract

Background: Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure. Objective: The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure Materials and Methods: 0.5 ml (300 μg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy. Results: The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043). Conclusion: GCSF can improve pregnancy outcome in patients with history of implantation failure. © 2016, Research and Clinical Center for Infertitlity. All rights reserved.