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Organic–Inorganic Hybrid Nanoflowers As a New Biomimetic Platform for Ros-Induced Apoptosis by Photodynamic Therapy Publisher Pubmed



Borghei YS1 ; Hamidieh AA2 ; Lu Y3 ; Hosseinkhani S4
Authors
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Authors Affiliations
  1. 1. Center for Bioscience & Technology, Institute for Convergence Science & Technology, Sharif University of Technology, Iran
  2. 2. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  4. 4. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Source: European Journal of Pharmaceutical Sciences Published:2023


Abstract

We report here a newly and facile synthesis of the phospholipids@gold nanoflowers (AuNFs) from intact cells as a new biomimetic organic-inorganic hybrid. The most appealing feature of this nanostructure is its dual-absorbing peak in near infrared (NIR) and visible region of spectra, which makes them a potential light-sensitive agent for reactive oxygen species (ROS)-induced apoptosis. Here, in contrast to previous studies, proposed nanostructures are synthesized in a one-pot reaction using phospholipids present in living cell membranes (as a donor cell) with detectable micro process of AuNF formation. The properties of the resulting AuNFs were evaluated through transmission electron microscopy (TEM), as well as FT-IR, 31P-NMR spectra and UV–Vis spectroscopy. Designed cell membrane-based nanostructure looks like an intact cell and would be able to interact with other cells (as a target cell) and also capable to produce cytotoxic singlet oxygen under NIR irradiation. Generated ROS act as a key player in initiation of programmed cell death (apoptosis) and progress of cancer photodynamic therapy (PDT). Cellular experiments on breast cancer MCF-7 cells demonstrated that they may be effective as photodynamic therapy agents. © 2023
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