Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms

Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms Publisher Pubmed

Akrami M¹ ; Balalaie S² ; Hosseinkhani S^{3, 4} ; Alipour M⁴ ; Salehi F⁵ ; Bahador A⁶ ; Haririan I^{1, 7}

Show Affiliations

1. Department of Pharmaceutical Biomaterials, Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Peptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran, Iran
3. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
4. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
5. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran
6. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Pharmaceutics, Tehran University of Medical Sciences, PO. Box 14155-6451, Tehran, Iran

Source: Scientific Reports Published:2016

Abstract

Pro-apoptotic peptides induce intrinsic apoptosis pathway in cancer cells. However, poor cellular penetration of the peptides is often associated with limited therapeutic efficacy. In this report, a series of peptide-gold nanoparticle platforms were developed to evaluate the anticancer activity of a novel alpha-lipoic acid-peptide conjugate, LA-WKRAKLAK, with respect to size and shape of nanoparticles. Gold nanoparticles (AuNPs) were found to enhance cell internalization as well as anticancer activity of the peptide conjugates. The smaller nanospheres showed a higher cytotoxicity, morphological change and cellular uptake compared to larger nanospheres and nanorods, whereas nanorods showed more hemolytic activity compared to nanospheres. The findings suggested that the anticancer and biological effects of the peptides induced by intrinsic apoptotic pathway were tuned by peptide-functionalized gold nanoparticles (P-AuNPs) as a function of their size and shape.

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Rassoul Dinarvand (2)

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Style	Citing Format
MLA	Akrami M, et al.. "Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms." Scientific Reports, vol. 6, no. , 2016, pp. -.
APA	Akrami M, Balalaie S, Hosseinkhani S, Alipour M, Salehi F, Bahador A, Haririan I (2016). Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms. Scientific Reports, 6(), -.
Chicago	Akrami M, Balalaie S, Hosseinkhani S, Alipour M, Salehi F, Bahador A, Haririan I. "Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms." Scientific Reports 6, no. (2016): -.
Harvard	Akrami M et al. (2016) 'Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms', Scientific Reports, 6(), pp. -.
Vancouver	Akrami M, Balalaie S, Hosseinkhani S, Alipour M, Salehi F, Bahador A, et al.. Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms. Scientific Reports. 2016;6():-.
BibTex	@article{ author = {Akrami M and Balalaie S and Hosseinkhani S and Alipour M and Salehi F and Bahador A and Haririan I}, title = {Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms}, journal = {Scientific Reports}, volume = {6}, number = {}, pages = {-}, year = {2016} }
RIS	TY - JOUR AU - Akrami M AU - Balalaie S AU - Hosseinkhani S AU - Alipour M AU - Salehi F AU - Bahador A AU - Haririan I TI - Tuning the Anticancer Activity of a Novel Pro-Apoptotic Peptide Using Gold Nanoparticle Platforms JO - Scientific Reports VL - 6 IS - SP - EP - PY - 2016 ER -

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