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International Clinimetric Evaluation of the Mg-Qol15, Resulting in Slight Revision and Subsequent Validation of the Mg-Qol15r Publisher Pubmed



Burns TM1 ; Sadjadi R2 ; Utsugisawa K3 ; Gwathmey KG1 ; Joshi A1 ; Jones S1 ; Bril V4 ; Barnett C4 ; Guptill JT5 ; Sanders DB5 ; Hobsonwebb L5 ; Juel VC5 ; Massey J5 ; Gable KL5 Show All Authors
Authors
  1. Burns TM1
  2. Sadjadi R2
  3. Utsugisawa K3
  4. Gwathmey KG1
  5. Joshi A1
  6. Jones S1
  7. Bril V4
  8. Barnett C4
  9. Guptill JT5
  10. Sanders DB5
  11. Hobsonwebb L5
  12. Juel VC5
  13. Massey J5
  14. Gable KL5
  15. Silvestri NJ6
  16. Wolfe G6
  17. Cutter G7
  18. Nagane Y3
  19. Murai H8
  20. Masuda M9
  21. Farrugia ME10
  22. Carmichael C10
  23. Birnbaum S11
  24. Hogrel JY11
  25. Nafissi S12
  26. Fatehi F12
  27. Ou C13
  28. Liu W13
  29. Conaway M1

Source: Muscle and Nerve Published:2016


Abstract

Introduction: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. Methods: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. Results: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. Conclusions: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015–1022, 2016. © 2016 Wiley Periodicals, Inc.
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