Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dynamic Changes of Epigenetic Signatures During Chondrogenic and Adipogenic Differentiation of Mesenchymal Stem Cells Publisher Pubmed



Saidi N1 ; Ghalavand M2 ; Hashemzadeh MS2 ; Dorostkar R2 ; Mohammadi H3, 4 ; Mahdianshakib A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
  2. 2. Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2017


Abstract

Extensive studies have been performed to clarify the processes during which mesenchymal stem cells (MSCs) differentiate into their lineage fates. In vitro differentiation of MSCs into distinct lineages have attracted the focus of a large number of clinical investigations. Although the gene expression profiling during differentiation of MSC toward bone, cartilage, and adipocytes is well established, the master regulators by which MSC fate can be controlled are not entirely determined. During differentiation of MSCs into a special cell fate, epigenetic mechanisms considered as the primary mediators that suppress the irrelevant genes and activate the genes required for a specific cell lineage. This review dedicated to addressing the changes of various epigenetic mechanisms, including DNA methylation, histone modifications, and micro-RNAs during chondrogenic and adipogenic differentiation of MSC. © 2017 Elsevier Masson SAS
Related Docs
View other Related Docs
1. Epigenetic Regulation of Specific Transcription Factors in Osteogenic Differentiation of Mesenchymal Stem Cells, Turkish Journal of Biology (2016)
2. Sirna and Epigenetic Aberrations in Ovarian Cancer, Journal of Cancer Research and Therapeutics (2016)
3. Application of Nanomaterials in Three-Dimensional Stem Cell Culture, Journal of Cellular Biochemistry (2019)
4. Inflammation Related Mirnas As an Important Player Between Obesity and Cancers, Journal of Diabetes and Metabolic Disorders (2019)
5. Epigenetics in Osteoarthritis: Novel Spotlight, Journal of Cellular Physiology (2019)
6. Epigenetic Regulation and Transcriptional Memory in Development; Selection Facilitating Prudence, International Journal of Developmental Biology (2020)
7. Dna Methylation and Histone Acetylation Patterns in Cultured Bovine Adipose Tissue-Derived Stem Cells (Badscs), Cell Journal (2015)
8. Epigenetic Alterations Underlying Autoimmune Diseases, Autoimmunity (2016)
Experts (# of related papers)
View all Related Experts
Bagher Larijani (3)
Hamid Reza Mirzaei (2)
Other Related Docs
9. Comparative Immunophenotypic Characteristics, Proliferative Features, and Osteogenic Differentiation of Stem Cells Isolated From Human Permanent and Deciduous Teeth With Bone Marrow, Molecular Biotechnology (2016)
10. Epigenetic Alterations and Exposure to Air Pollutants: Protocol for a Birth Cohort Study to Evaluate the Association Between Adverse Birth Outcomes and Global Dna Methylation, JMIR Research Protocols (2017)
11. The Effect of Increased Mir-16-1 Levels in Mouse Embryos on Epigenetic Modification, Target Gene Expression, and Developmental Processes, Reproductive Sciences (2020)
12. Epigenetic Strategies to Boost Car T Cell Therapy, Molecular Therapy (2021)
13. The Inter-Talk Between Mycobacterium Tuberculosis and the Epigenetic Mechanisms, Epigenomics (2020)
14. Induced Pluripotent Stem Cells As a New Getaway for Bone Tissue Engineering: A Systematic Review, Cell Proliferation (2017)
15. The Paradox of Th17 Cell Functions in Tumor Immunity, Cellular Immunology (2017)
16. Glance Into Cancer Stem Cells, Journal of Kerman University of Medical Sciences (2016)
17. Investigation of 3T3-L1 Cell Differentiation to Adipocyte, Affected by Aqueous Seed Extract of Phoenix Dactylifera L, Reports of Biochemistry and Molecular Biology (2020)
18. Stem Cell-Based Approach for the Treatment of Parkinson's Disease, Medical Journal of the Islamic Republic of Iran (2015)
19. Stem Cells Have More Than Five Senses, Biophysics and Neurophysiology of the Sixth Sense (2019)
20. Differential Role of Micrornas in Prognosis, Diagnosis, and Therapy of Ovarian Cancer, Biomedicine and Pharmacotherapy (2016)
21. Mesenchymal Stem Cells: Rising Concerns Over Their Application in Treatment of Type One Diabetes Mellitus, Journal of Diabetes Research (2015)
22. Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to Be Aware Of, Current Pharmaceutical Biotechnology (2021)
23. Cartilage Tissue and Therapeutic Strategies for Cartilage Repair, Current Molecular Medicine (2021)
24. How Does the Supernatant of Lactobacillus Acidophilus Affect the Proliferation and Differentiation Activities of Rat Bone Marrow-Derived Stromal Cells?, Cellular and Molecular Biology (2016)
25. Effects of Endothelial and Mesenchymal Stem Cells on Improving Myocardial Function in a Sheep Animal Model, Journal of Tehran University Heart Center (2017)
26. Toward in Vitro Production of Platelet From Induced Pluripotent Stem Cells, Stem Cell Reviews and Reports (2022)
27. Male Factors: The Role of Sperm in Preimplantation Embryo Quality, Reproductive Sciences (2021)
28. The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases, Molecular Neurobiology (2019)
29. Association Between Alterations in Global Dna Methylation and Predisposing Factors in Diabetes: A High Pressure Liquid Chromatography Based Study, Minerva Medica (2015)
30. A Review on Leukemia and Ipsc Technology: Application in Novel Treatment and Future, Current Stem Cell Research and Therapy (2018)
31. Current Advances in Stem Cell Therapy in the Treatment of Multiple Sclerosis, Reviews in the Neurosciences (2023)
32. Effect of Morphine Exposure on Novel Object Memory of the Offspring: The Role of Histone H3 and Δfosb, Brain Research Bulletin (2020)
33. Micrornas Implications in the Onset, Diagnosis, and Prognosis of Osteosarcoma, Current Molecular Medicine (2021)
34. Epigenetic Mechanisms Underlying the Toxic Effects Associated With Arsenic Exposure and the Development of Diabetes, Food and Chemical Toxicology (2017)
35. Reciprocal Interconnection of Mirnome-Epigenome in Cancer Pathogenesis and Its Therapeutic Potential, Epigenetics Territory and Cancer (2015)
36. Apoptotic Effect of Resveratrol on Human T-All Cell Line Ccrf-Cem Is Unlikely Exerted Through Alteration of Bax and Bcl2 Promoter Methylation, Journal of Cellular Biochemistry (2018)
37. Environmental Toxicant Exposure and Cancer: The Role of Epigenetic Changes and Protection by Phytochemicals, Current Pharmaceutical Design (2015)
38. Novel Cell-Based Therapies in Hepatic Disorders, Journal of Mazandaran University of Medical Sciences (2020)
39. Dna Methylation in Human Diseases, Heliyon (2024)
40. Co-Expression of Cancer Stem Cell Markers Oct4 and Nanog Predicts Poor Prognosis in Renal Cell Carcinomas, Scientific Reports (2018)
41. Reprogramming of Endometrial Adult Stromal Cells in the Presence of a Rock Inhibitor, Thiazovivin, Could Obtain More Efficient Ipscs, Cell Biology International (2015)
42. Stem Cell Transplantation As a Progressing Treatment for Retinitis Pigmentosa, Cell and Tissue Research (2022)