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Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cells (Bmscs) Affects Serum Ige and Lung Cytokines Levels in Sensitized Mice Publisher Pubmed



Mohammadian M1 ; Sadeghipour HR2 ; Jahromi GP3 ; Jafari M4 ; Nejad AK5 ; Khamse S2 ; Boskabady MH6
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Emergency Medical Services, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Cytokine Published:2019


Abstract

Introduction: The effects of bone marrow-derived mesenchymal stem cells (BMSCs) and simvastatin combination therapy on serum total and specific IgE levels and lung IL-13 and TGF-β levels in sensitized mouse were examined. Material and methods: Control (n = 5), Sensitized (S), (n = 5), S + BMSC (n = 6), S + simvastatin (n = 6) and S + BMSC + simvastatin (n = 4) groups of BALB/c mice were studied. Mice were sensitized by ovalbumin. Sensitized mice were treated with a single intravenous injection of BMSCs (1 × 106) or daily intraperitoneal injection of simvastatin (40 mg/kg) or both BMSCs and simvastatin on the last week of challenge. Serum total and ovalbumin specific IgE levels as well as IL-13 and TGF-β levels in broncho-alveolar lavage (BAL) fluid were evaluated. Results: Serum total and specific IgE levels as well as lung IL-13 and TGF-β levels were significantly increased in S group compared to control group (P < 0.001 for all cases). Treatment with BMSCs, simvastatin and their combination significantly decreased serum total and specific IgE levels (P < 0.05 to P < 0.01). However, IL-13 and TGF-β levels were significantly decreased by BMSCs and BMSC + simvastatin combination therapy (P < 0.05 for all cases). The effect of simvastatin and BMSCs combination therapy on serum specific IgE levels as well as lung IL-13 and TGF-β levels were significantly higher than the effect of BMSCs and simvastatin alone (P < 0.001 for IL-13 and P < 0.01 for other cases). Conclusions: Simvastatin and BMSCs combination therapy affects serum IgE as well as lung IL-13 and TGFβ levels more than BMSC therapy and simvastatin therapy alone which may be due to increased BMSCs migration into the lung tissue. © 2018 Elsevier Ltd