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Effects of Nigella Sativa on Glycemic Control, Lipid Profiles, and Biomarkers of Inflammatory and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials Publisher Pubmed



Hallajzadeh J1 ; Milajerdi A2, 3 ; Mobini M4 ; Amirani E5 ; Azizi S6 ; Nikkhah E7 ; Bahadori B7 ; Sheikhsoleimani R8 ; Mirhashemi SM9
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran
  2. 2. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
  5. 5. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Student Research Committe, Maragheh University of Medical Sciences, Maragheh, Iran
  7. 7. Medicinal Plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran
  8. 8. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  9. 9. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran

Source: Phytotherapy Research Published:2020


Abstract

The aim of this systematic review and meta-analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity among the included studies were assessed using the Cochrane's Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. A total of 50 trials were included in this meta-analysis. We found a significant reduction in total cholesterol (WMD: −16.80; 95% CI: −21.04, −12.55), triglycerides (WMD: −15.73; 95% CI: −20.77, −10.69), LDL-cholesterol (WMD: −18.45; 95% CI: −22.44, −14.94) and VLDL-cholesterol (WMD: −3.72; 95% CI: −7.27, −0.18) following supplementation with N. sativa. In addition, there was significant reductive effect observed with N. sativa on fasting glucose (WMD: −15.18; 95% CI: −19.82, −10.55) and HbA1C levels (WMD: −0.45; 95% CI: −0.66, −0.23). Effects of N. sativa on CRP (WMD: −3.61; 95% CI: −9.23, 2.01), TNF-α (WMD: −1.18; 95% CI: −3.23, 0.86), TAC (WMD: 0.31; 95% CI: 0.00, 0.63), and MDA levels (WMD: −0.95; 95% CI: −2.18, 0.27) were insignificant. This meta-analysis demonstrated the beneficial effects of N. sativa on fasting glucose, HbA1c, triglycerides, total-, VLDL-, LDL-cholesterol levels. © 2020 John Wiley & Sons, Ltd.
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