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Pyrexia in Human Herpesvirus 6 (Hhv6)-Infected Patients: A Systems Virology Study Publisher



Chenari M1 ; Forghaniramandi MM2 ; Taherzadehghafarokhi N2 ; Mokhtariazad T1 ; Shadabi S2 ; Mozhgani SH3, 4 ; Arjmand R5 ; Mohammadhosayni M6 ; Karami H1 ; Rezaei F1
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Department of Pediatric, Emam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2021


Abstract

Given the critical function of HHV6 in the development of fever, rashes, febrile convulsions, encephalitis, and other serious diseases in immunocompromised patients, understanding the pathogenesis and cardinal cellular pathways involved in the virus's pathogenicity is essential. For this purpose a gene expression dataset was obtained from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEG) were identified based on their log fold change (LogFc) values. Seventy DEGs were found in the HHV6 vs. healthy control gene expression profile, with 68 upregulated and 2 downregulated genes. According to enrichment results, DEGs linked to inflammatory pathways were selected for further evaluations. Signaling network involved in HHV6 mediated Pyrexia was constructed based on gene interactions stored in Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We discovered seven genes with high probabilities of being involved in the febrile reaction triggered by HHV6 using functional enrichment analysis. These genes include as follows: AIM2, CCL2, CASPAS 5, ZBP1, ISG15, IRF7, and CXCL10. Understanding the virus's pyrogenic pathway will help us to gain a deeper understanding of the disease. These DEGs are involved in a various aspects of inflammatory responses, most notably in the regulation of endogenous pyrogens that trigger fever. © 2021 Elsevier Inc.