Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature

Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature Publisher Pubmed

Aghili M^{1, 3} ; Kolahdouzan K^{1, 3} ; Shabani M² ; Jafari F^{1, 3} ; Jaberi R^{1, 4}

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1. Radiation Oncology Research Center (RORC), Cancer Institute, Imam Khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran
2. Studentsâ€™ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Physics, University of Surrey, Guildford, United Kingdom

Source: Brachytherapy Published:2022

Abstract

PURPOSE: Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma, mostly involving the genitourinary (GU) tract, head and neck, and extremities. This study reports the long-term outcome of two infants with recurrent GU-RMS who underwent combination therapy with chemotherapy (ChT) and salvage brachytherapy (BT). METHODS AND MATERIALS: An 18-month-old girl with vaginal bleeding and a 7-month-old boy with urinary retention presented with a diagnosis of vaginal, and bladder/prostate embryonal RMS, respectively. Surgical resection and ChT were done for both patients. However, both developed local recurrences after one year and subsequently, underwent second-line ChT and salvage interstitial high dose rate BT. RESULTS: The clinical target volumes for the first and second patients were treated to a totaldose of 32 Gy in 10 fractions and 35 Gy in 10 fractions, respectively, with two fractions delivered per day with a 6-h interval between fractions. After 9 years of follow-up, both patients are alive with natural growth and no late complication or evidence of recurrence. CONCLUSIONS: Our report shows that BT (for patients with no prior history of irradiation) could result in long-term disease-free survival in well-selected pediatric patients with recurrent GU embryonal RMS without inflicting expected adverse effects of external beam radiotherapy. © 2022 American Brachytherapy Society

Style	Citing Format
MLA	Aghili M, et al.. "Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature." Brachytherapy, vol. 21, no. 4, 2022, pp. 494-500.
APA	Aghili M, Kolahdouzan K, Shabani M, Jafari F, Jaberi R (2022). Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature. Brachytherapy, 21(4), 494-500.
Chicago	Aghili M, Kolahdouzan K, Shabani M, Jafari F, Jaberi R. "Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature." Brachytherapy 21, no. 4 (2022): 494-500.
Harvard	Aghili M et al. (2022) 'Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature', Brachytherapy, 21(4), pp. 494-500.
Vancouver	Aghili M, Kolahdouzan K, Shabani M, Jafari F, Jaberi R. Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature. Brachytherapy. 2022;21(4):494-500.
BibTex	@article{ author = {Aghili M and Kolahdouzan K and Shabani M and Jafari F and Jaberi R}, title = {Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature}, journal = {Brachytherapy}, volume = {21}, number = {4}, pages = {494-500}, year = {2022} }
RIS	TY - JOUR AU - Aghili M AU - Kolahdouzan K AU - Shabani M AU - Jafari F AU - Jaberi R TI - Long-Term Disease-Free Survival Following Salvage Brachytherapy for Recurrent Pediatric Rhabdomyosarcoma: Two Case Reports and Review of Relevant Literature JO - Brachytherapy VL - 21 IS - 4 SP - 494 EP - 500 PY - 2022 ER -

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