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Chimeric Antigen Receptor T-Cell Therapy for Breast Cancer Publisher Pubmed



Gharghani MS1 ; Simonian M2 ; Bakhtiari F3 ; Ghaffari MH2 ; Fazli G4 ; Bayat AA4 ; Negahdari B2
Authors
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Authors Affiliations
  1. 1. Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, 8415683111, Iran
  2. 2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 14177-55469, Iran
  3. 3. Department of Laboratory Sciences, Faculty of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran
  4. 4. Monoclonal Antibody Research Center, Avicenna Research Institute, Acecr, Tehran, Iran

Source: Future Oncology Published:2021


Abstract

One of the main reasons that researchers pay enormous attention to immunotherapy is that, despite significant advances in conventional therapy approaches, breast cancer remains the leading cause of death from malignant tumors among women. Genetically modifying T cells with chimeric antigen receptors (CAR) is one of the novel methods that has exhibited encouraging activity with relative safety, further urging investigators to develop several CAR T cells to target overexpressed antigens in breast tumors. This article is aimed not only to present such CAR T cells and discuss their remarkable results but also indicates their shortcomings with the hope of achieving possible strategies for improving therapeutic response. © 2021 Future Medicine Ltd.
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