Systematic Review of the Association Between Bmi and Antimullerian Hormone (Amh) Levels in Reproductive Aged Women



Moslehi N¹ ; Shabbidar S² ; Ramezani Tehrani F³ ; Mirmiran P^{1, 4} ; Azizi F⁵ Show Affiliations
Source: Iranian Journal of Endocrinology and Metabolism Published:2018

Abstract

Introduction: The aim of the current study was to systematically review studies on the associations of obesity or body mass index (BMI) with anti-mullerian hormone (AMH). Materials and Methods: PubMed and Scopus databases were searched using the appropriate keywords. Original studies published up to December 2016, that evaluated the independent associations of BMI or obesity with AMH in reproductive aged women, were considered eligible. Results: In this study, 26 articles were included. Based on Polycystic ovarian syndrome (PCOS) and fertility status, participants were divided into three groups of PCOS women, infertile non-PCOS women, and fertile and non-PCOS women. Seven of 11 studies on PCOS, 3 of 7 studies on infertile and 4 of 5 studies on non- PCOS women, reported negative correlations between BMI and AMH. However, strength of the correlations were weak (mostly less than 0.3). Four out of 6 studies on PCOS women, 1 out of 3 on infertile women, and 2 out of the 7 on fertile non-PCOS women reported a significant lower AMH level in obese than in non-obese women. Conclusion: The association between BMI and ovarian reserve is not clear according to the current findings. © 2018, Endocrine Research Center. All right reserved.