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Tlr9-Based Immunotherapy for the Treatment of Allergic Diseases Publisher Pubmed



Farrokhi S1 ; Abbasirad N1 ; Movahed A2 ; Khazaei HA3 ; Pishjoo M4 ; Rezaei N5
Authors
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Authors Affiliations
  1. 1. Department of Immunology Asthma and Allergy, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
  2. 2. Department of Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran
  3. 3. Clinical Immunology Research Center, Department of Immunology and Hematology, Zahedan University of Medical Sciences, Zahedan, Iran
  4. 4. Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  5. 5. Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran

Source: Immunotherapy Published:2017


Abstract

Toll-like receptors (TLRs), a family of pattern recognition receptors expressed on many cell types of innate immunity, recognize the pathogen-associated molecular patterns of microbes. The hygiene hypothesis suggests that a reduced microbial exposure in early childhood increases the susceptibility to allergic diseases due to deviation in development of the immune system. TLRs are key roles in the right and healthy direction of adaptive immunity with the induction of T-helper 2 toward Th1 immune responses and regulatory T cells. TLR ligand CpG-ODN-based immunomodulation is independent of allergen and it mainly affects innate immune system. While, CpG-oligodeoxynucleotide-based vaccination is allergen specific and induces adaptive immune system. The use of agonists of TLR9 in two distinct strategies of immunotherapy, immunomodulation and vaccination, could be presented as the curative method for the treatment of allergic diseases. © 2017 Future Medicine Ltd.
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