Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds

Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds Publisher Pubmed

Omidpanah S¹ ; Vahedimazdabadi Y² ; Manayi A¹ ; Rastegari A² ; Hariri R³ ; Mortazaviardestani E⁴ ; Eftekhari M⁵ ; Khanavi M⁵ ; Akbarzadeh T^{2, 3} ; Saeedi M^{1, 2}

Show Affiliations

1. Faculty of Pharmacy, Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. School of Pharmacy, International Campus (TUMS-IC), Tehran University of Medical Sciences, Tehran, Iran
5. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Natural Product Research Published:2020

Abstract

In this work, n-hexane, chloroform, and ethyl acetate fractions of the methanol extract of Myristica fragrans Houtt. seeds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via Ellman’s method. It was found that all fractions depicted no anti-AChE activity, however, they were active toward BChE with IC50 values of 361.8, 215.0, and 145.8 µg/mL, respectively comparing with donepezil as the reference drug (IC50 = 1.97 µg/mL). The ethyl acetate fraction which also showed high neuroprotectivity and metal chelating ability was selected for the phytochemical analysis. Our results confirmed the presence of trimyristin and 5,7-diacetyl chrysin (reported for the first time in M. fragrans) in the corresponding fraction. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Omidpanah S, et al.. "Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds." Natural Product Research, vol. , no. , 2020, pp. 1-7.
APA	Omidpanah S, Vahedimazdabadi Y, Manayi A, Rastegari A, Hariri R, Mortazaviardestani E, Eftekhari M, Khanavi M, Akbarzadeh T, Saeedi M (2020). Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds. Natural Product Research, (), 1-7.
Chicago	Omidpanah S, Vahedimazdabadi Y, Manayi A, Rastegari A, Hariri R, Mortazaviardestani E, Eftekhari M, Khanavi M, Akbarzadeh T, Saeedi M. "Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds." Natural Product Research , no. (2020): 1-7.
Harvard	Omidpanah S et al. (2020) 'Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds', Natural Product Research, (), pp. 1-7.
Vancouver	Omidpanah S, Vahedimazdabadi Y, Manayi A, Rastegari A, Hariri R, Mortazaviardestani E, et al.. Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds. Natural Product Research. 2020;():1-7.
BibTex	@article{ author = {Omidpanah S and Vahedimazdabadi Y and Manayi A and Rastegari A and Hariri R and Mortazaviardestani E and Eftekhari M and Khanavi M and Akbarzadeh T and Saeedi M}, title = {Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds}, journal = {Natural Product Research}, volume = {}, number = {}, pages = {1-7}, year = {2020} }
RIS	TY - JOUR AU - Omidpanah S AU - Vahedimazdabadi Y AU - Manayi A AU - Rastegari A AU - Hariri R AU - Mortazaviardestani E AU - Eftekhari M AU - Khanavi M AU - Akbarzadeh T AU - Saeedi M TI - Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds JO - Natural Product Research VL - IS - SP - 1 EP - 7 PY - 2020 ER -

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