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The Effect of French Maritime Pine Bark Extract Supplementation on Inflammation, Nutritional and Clinical Status in Critically Ill Patients With Traumatic Brain Injury: A Randomized Controlled Trial Publisher Pubmed



Malekahmadi M1, 2 ; Shadnoush M3 ; Islam SMS4 ; Shirvani A5 ; Pahlavani N6, 7 ; Gholizadeh Navashenaq J8 ; Firouzi S1 ; Mcvicar J4 ; Nematy M2 ; Zali MR1 ; Moradi Moghaddam O9 ; Norouzy A2
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia
  5. 5. Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  7. 7. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  8. 8. Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran
  9. 9. Trauma and Injury Research Center, Critical Care Department, Rasoul-e-Akram Complex Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: Phytotherapy Research Published:2021


Abstract

Inflammation plays an important role in the pathophysiology of traumatic brain injury (TBI). Based on the anti-inflammatory properties of French maritime pine bark extract and the neuroprotective effects, we aimed to evaluate the effects of its supplementation on TBI. Sixty-seven TBI patients admitted to the intensive care units (ICUs) were enrolled. After stabilizing the hemodynamic status, the intervention group received 150 mg of French maritime pine bark extract supplementation (Oligopin) with enteral nutrition for 10 days. The control group received a placebo. Inflammatory status and oxidative stress markers were measured three times. Also, clinical and nutritional statuses were assessed. Supplementation, significantly decreased IL-6 (β = −53.43 pg/ml, 95% confidence interval [CI] = −91.74, −15.13, p =.006), IL-1β (β = −111.66 pg/ml, 95% CI = −183.79, −39.5402, p =.002) and C-reactive protein (β = −19.99 mg/L, 95% CI = −27.23, −12.76, p ˃.001) in the intervention group compared to control group after 10 days. Clinical scores including acute physiology and chronic health evaluation II and sequential organ failure assessment were reduced (β = −3.72, 95% CI = −5.96, −1.49, p =.001and β = −2.07, 95% CI = −3.23, −0.90, p <.001, respectively), and Nutric score was reduced compared to control group (β = −.60, 95% CI = −1.08, −0.12, p =.01). The survival rate was higher by 15% in the intervention group compared to control group. Oligopin supplementation in TBI patients in ICU reduced inflammation and improved the clinical status and malnutrition score and thereby reducing the mortality rate. © 2021 John Wiley & Sons Ltd.