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Unstimulated Salivary P53 in Patients With Oral Lichen Planus and Squamous Cell Carcinoma Pubmed



Aghahosseini F1 ; Mirzaiidizgah I2 ; Mirizarandi NS1
Authors
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Authors Affiliations
  1. 1. Department of Oral Medicine, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran

Source: Acta Medica Iranica Published:2015


Abstract

Unstimulated whole salivary p53 was evaluated in non-involved subjects, in patients suffering from oral lichen planus (OLP) and squamous cell carcinoma (SCC). A total of 34 patients with OLP, 24 patients suffering from oral SCC and 41 non-involved participants were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA. Data was analyzed by ANOVA followed by the Tukey post hoc test. Saliva p53 concentration in patients with SCC (5.36±1.08) was significantly higher than in healthy participants (0.41±0.04) and in patients suffering from OLP (0.94±0.31). This study could not confirm the precancerous nature of OLP based on the relatively low p53 expressions in comparison to SCC. © 2015 Tehran University of Medical Sciences. All rights reserved.
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