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A Review of Salivary Biomarkers in Breast Cancer Publisher



Koopaie M1 ; Fatahzadeh M2 ; Kolahdooz S3 ; Mousavi R4
Authors
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Authors Affiliations
  1. 1. Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Division of Oral Medicine, Rutgers School of Dental Medicine, Newark, NJ, United States
  3. 3. Universal Scientific, Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran

Source: Current Women's Health Reviews Published:2023


Abstract

Objectives: This study aimed to review the literature related to salivary biomarkers used to diagnose breast cancer or predict responses to therapy and its prognosis. Methods: Studies were eligible for inclusion if they had compared salivary diagnostics for breast cancer with the gold standard or other biomarkers. Six databases (PubMed, EMBASE, ScienceDi-rect, Scopus, Web of Science, and Ovid) and Google Scholar search engine searched for pertinent literature using specific search terms: breast cancer, diagnosis, prognosis saliva, and salivary bi-omarker. Of the 513 studies screened, 110 were selected for inclusion in this review. Different salivary biomarkers were classified and discussed. Results: Our analysis indicated that the sensitivity and specificity of salivary biomarkers, such as c-erb-B2 and sialic acid in BC detection are comparable with serum values. Salivary levels of autoan-tibodies against MUC1, CA 15-3, and adiponectin had a better correlation with breast cancer than serum levels. Assessment of biomarkers, such as HER-2, helps develop a treatment plan and evalu-ates response to treatment. Conclusion: Our study confirms that salivary biomarkers are becoming increasingly important in breast cancer diagnosis and treatment planning, as well as in predicting therapeutic response and prognosis. Salivary biomarkers such as c-erb-B2 in association with traditional criteria offer the promise of use as a noninvasive screening method for breast cancer. Additional studies are warrant-ed to determine the most sensitive and specific salivary biomarkers for this purpose. © 2023 Bentham Science Publishers.
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