Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates

Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates Publisher

Dahiru Rogo L^{1, 2} ; Rezaei F^{1, 3} ; Shafieijandaghi NZ^{1, 3} ; Ghavami N^{1, 3} ; Fateminasab G^{1, 3} ; Mokhtariazad T^{1, 3}

Show Affiliations

1. Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran
2. Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University Kano, PMB 3011, Nigeria
3. National Influenza Center, Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2015

Abstract

Aim: Roles of NS gene of influenza A virus in virulence and replication are well established but extent of its variation in seasonal influenza A (H3N2) viruses in Iran is not well known. Materials & methods: NS gene of 37 (A/H3N2) virus isolates were sequenced and analyzed for information on genetic changes. Results: Data analysis of NS1 protein revealed two amino acid substitutions E26K and Q193R in almost all strains. Substitutions in T58P in 27.0%, A86S in 13.5% and each of V11G, M81I and P85T in 2.7% Iranian strains were also observed. Mutations in NS2/NEP protein were observed in K36E, Q101L and F107S. Conclusion: Many mutations were observed for the first time in Iranian strains. Their function remains to be determined. © 2015 Future Medicine Ltd.

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Style	Citing Format
MLA	Dahiru Rogo L, et al.. "Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates." Future Virology, vol. 10, no. 11, 2015, pp. 1195-1206.
APA	Dahiru Rogo L, Rezaei F, Shafieijandaghi NZ, Ghavami N, Fateminasab G, Mokhtariazad T (2015). Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates. Future Virology, 10(11), 1195-1206.
Chicago	Dahiru Rogo L, Rezaei F, Shafieijandaghi NZ, Ghavami N, Fateminasab G, Mokhtariazad T. "Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates." Future Virology 10, no. 11 (2015): 1195-1206.
Harvard	Dahiru Rogo L et al. (2015) 'Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates', Future Virology, 10(11), pp. 1195-1206.
Vancouver	Dahiru Rogo L, Rezaei F, Shafieijandaghi NZ, Ghavami N, Fateminasab G, Mokhtariazad T. Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates. Future Virology. 2015;10(11):1195-1206.
BibTex	@article{ author = {Dahiru Rogo L and Rezaei F and Shafieijandaghi NZ and Ghavami N and Fateminasab G and Mokhtariazad T}, title = {Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates}, journal = {Future Virology}, volume = {10}, number = {11}, pages = {1195-1206}, year = {2015} }
RIS	TY - JOUR AU - Dahiru Rogo L AU - Rezaei F AU - Shafieijandaghi NZ AU - Ghavami N AU - Fateminasab G AU - Mokhtariazad T TI - Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates JO - Future Virology VL - 10 IS - 11 SP - 1195 EP - 1206 PY - 2015 ER -

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